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Antibodies
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anti-Integrin, alpha L (Antigen CD11A (p180), Lymphocyte Function-Associated Antig...
Integrin, alpha L (Antigen CD11A (p180), Lymphocyte Function-Associated Antigen 1; alpha Polypeptide) (ITGAL) antibody (FITC)
| Antigen |
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| Synonyms |
CD11A, LFA-1, LFA1A, Cd11a, Ly-15, Ly-21, ITGAL, CD11a |
| Clonality |
Monoclonal (M17-4) |
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Host
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Reactivity
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Conjugate
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Application
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| Catalog no. |
ABIN457347 |
| Quantity |
0.1 mg (0.5 mg/ml) |
| Price |
286.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 3 to 5 Business Days |
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Alternative name
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CD11a
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Immunogen
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C57BL/6 mouse splenic secondary cytotoxic T lymphocytes
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Isotype
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IgG2a
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Clone
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M17-4
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Description
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CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1(LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex.LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation.Cell stimulation by chemokines or other signals leads to induction the high-affinityconformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesionmolecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells andin their tissue-specific settlement, but participates also in control of cell differentiation andproliferation and of T-cell effector functions.
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Specificity
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The rat monoclonal antibody M17/4 reacts with CD11a (alpha-subunit of murine LFA-1), a180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes,monocytes, macrophages, neutrophils, basophils and eosinophils.
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Application Notes
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The reagent is designed for Flow Cytometry analysis. Suggested working concentration is 3 µg/ml. Indicated dilution is recommended startingpoint for use of this product. Working concentrations should be determined by the investigator.
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Concentration
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0.5 mg/ml
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Buffer
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Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Storage
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Store in the dark at 2-8 o C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
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Research Area
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Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
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Restrictions
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For Research Use only
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Alternatives for antigen "Integrin, alpha L (Antigen CD11A (p180), Lymphocyte Function-Associated Antigen 1; alpha Polypeptide) (ITGAL)", type "Antibodies"
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Hosts
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Mouse (58), Rat (37)
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Reactivities
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Human (42), Mouse (Murine) (39), Rat (Rattus) (7), Cow (Bovine) (3), Rabbit (3), Dog (Canine) (2), Pig (Porcine) (2)
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Applications
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Flow Cytometry (FACS) (78), Immunoprecipitation (IP) (20), Functional Studies (Func) (13), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunohistochemistry (IHC) (5), Blocking Antibody (Inhibition) (4), Immunocytochemistry (ICC) (2), Immunofluorescence (IF) (2), Western Blotting (WB) (1)
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Conjugates
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FITC (19), Biotin (13), PE (10), RPE (7), APC (4), PE,Cy7 (2), Alexa Fluor 488 (1), Alexa Fluor 700 (1), Pacific Blue (1)
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Alternatives 
