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Antibodies
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anti-Integrin, alpha L (Antigen CD11A (p180), Lymphocyte Function-Associated Antig...
Integrin, alpha L (Antigen CD11A (p180), Lymphocyte Function-Associated Antigen 1; alpha Polypeptide) (ITGAL) antibody
| Antigen |
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| Synonyms |
CD11A, LFA-1, LFA1A, Cd11a, Ly-15, Ly-21, ITGAL, CD11a |
| Clonality |
Monoclonal (M17-4) |
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Host
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Reactivity
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| Catalog no. |
ABIN457403 |
| Quantity |
0.1 mg (1 mg/ml) (Variants) |
| Price |
247.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 3 to 5 Business Days |
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Alternative name
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CD11a
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Immunogen
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C57BL/6 mouse splenic secondary cytotoxic T lymphocytes
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Format
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Low Endotoxin
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Isotype
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IgG2a
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Clone
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M17-4
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Description
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CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1(LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex.LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation.Cell stimulation by chemokines or other signals leads to induction the high-affinityconformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesionmolecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells andin their tissue-specific settlement, but participates also in control of cell differentiation andproliferation and of T-cell effector functions.
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Specificity
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The rat monoclonal antibody M17/4 reacts with CD11a (alpha-subunit of murine LFA-1), a180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes,monocytes, macrophages, neutrophils, basophils and eosinophils.
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE)
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Purification
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Purified from cell culture supernatant by protein-G affinity chromatography.
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Buffer
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Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 µ m filter sterilized. Endotoxin level is less than 0.1 EU/ µ g of the protein, as determined by the LAL test.
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Storage
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Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
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Research Area
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Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
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Restrictions
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For Research Use only
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Alternatives for antigen "Integrin, alpha L (Antigen CD11A (p180), Lymphocyte Function-Associated Antigen 1; alpha Polypeptide) (ITGAL)", type "Antibodies"
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Hosts
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Mouse (58), Rat (37)
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Reactivities
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Human (42), Mouse (Murine) (39), Rat (Rattus) (7), Cow (Bovine) (3), Rabbit (3), Dog (Canine) (2), Pig (Porcine) (2)
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Applications
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Flow Cytometry (FACS) (79), Immunoprecipitation (IP) (20), Functional Studies (Func) (13), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunohistochemistry (IHC) (5), Blocking Antibody (Inhibition) (4), Immunocytochemistry (ICC) (2), Immunofluorescence (IF) (2), Western Blotting (WB) (1)
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Conjugates
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FITC (20), Biotin (13), PE (10), RPE (7), APC (4), PE,Cy7 (2), Alexa Fluor 488 (1), Alexa Fluor 700 (1), Pacific Blue (1)
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Alternatives 
