Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibody

Antigen: Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1)

Synonyms: CLG, CLGN, Dm1-MMP, l(2)k04809, mmp1, DmelCG4859, CG4859, MMP1, Mmp1a, Mmp1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN457517

Additional Information

Characteristics: 100 ug affinity purified rabbit anti-MMP-1 polyclonal antibody. Reacts with human. Reactivity to other species have not been determined. Recombinant human MMP-1 (Cat.# 7781-10) can be used as a positive control.

Alternative name: MMP-1

Immunogen: E. coli-expressed recombinant human MMP-1 (Cat.# 7781-10)

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I, II, III, VII and X.  MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.

Application Details

Application Notes: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.

Concentration: 0.5 mg/ml

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Storage: Store at -20°C. Shipped on gel packs. Shelf Life: 12 months.

Restrictions: For Research Use only