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Antibodies
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anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) antibody
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) antibody
| Antigen |
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| Synonyms |
BAM, BIM, BOD, BimL, BimEL, BIM-beta6, BIM-beta7, BIM-alpha6, Bim, Bod, 1500006F24Rik, bim |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
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| Catalog no. |
ABIN459425 |
| Quantity |
100µg (1 mg/ml) (Variants) |
| Price |
743.71 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Alternative name
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Bim
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Format
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Liquid
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Description
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Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS or BimL, implying a unique role for BimEL in cell survival signaling.
Synonyms: Bcl2-interacting mediator of cell death, BIM, BIM
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Specificity
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BIM-alpha/beta (A2) pAb detects endogenous levels of BIM-alpha/beta protein.
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Molecular Weight
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25 kDa
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Application Notes
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WB: 1:500-1:1000 IHC: 1:50-1:200
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE).
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Purification
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The pAb was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Buffer
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1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11)", type "Antibodies"
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Hosts
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Rabbit (48), Mouse (5), Goat (4), Rat (4), Hamster (3)
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Reactivities
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Human (57), Mouse (Murine) (42), Rat (Rattus) (33), Monkey (1)
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Applications
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Western Blotting (WB) (51), Immunofluorescence (IF) (21), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (18), Immunohistochemistry (IHC) (15), Enzyme Immunoassay (EIA) (9), Flow Cytometry (FACS) (7), Immunoprecipitation (IP) (7), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Immunocytochemistry (ICC) (4), ELISA (3)
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Conjugates
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Biotin (1)
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Epitopes
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pSer69/65 (4), AA 2-198 (2), Center (2), N-Term (2), pSer69 (2), BH3 Domain (1), C-Term (1)
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