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Antibodies
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anti-Janus Kinase 2 (JAK2) antibody
Janus Kinase 2 (JAK2) antibody
| Antigen |
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| Synonyms |
JTK10, Fd17, C81284, AI504024, JAK2, DKFZp469G074 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Western Blotting (WB) (36), Immunohistochemistry (IHC) (24), Immunofluorescence (IF) (21), Flow Cytometry (FACS) (18), ELISA (12), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), Enzyme Immunoassay (EIA) (8), Immunoprecipitation (IP) (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Dot Blot (Dot) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1)
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| Catalog no. |
ABIN459582 |
| Quantity |
100µg (1 mg/ml) (Variants) |
| Price |
743.71 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Alternative name
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JAK2
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Format
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Liquid
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Description
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Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Synonyms: Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2
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Specificity
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JAK2 (L1001) pAb detects endogenous levels of JAK2 protein.
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Molecular Weight
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130 kDa
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Application Notes
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WB: 1:500-1:1000 IHC: 1:50-1:200
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE).
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Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Buffer
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1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "Janus Kinase 2 (JAK2)", type "Antibodies"
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Hosts
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Rabbit (76), Mouse (4), Goat (2)
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Reactivities
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Human (74), Rat (Rattus) (59), Mouse (Murine) (52), Chicken (17), Cow (Bovine) (17), Dog (Canine) (16), Pig (Porcine) (16), Zebrafish (Brachydanio rerio) (1)
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Applications
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Western Blotting (WB) (36), Immunohistochemistry (IHC) (24), Immunofluorescence (IF) (21), Flow Cytometry (FACS) (18), ELISA (12), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), Enzyme Immunoassay (EIA) (8), Immunoprecipitation (IP) (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Dot Blot (Dot) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitopes
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pTyr1007 (9), pTyr221 (4), C-Term (3), pTyr1007, pTyr1008 (1)
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