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Antibodies
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anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibody
Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibody
| Antigen |
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| Synonyms |
CLG, CLGN, Dm1-MMP, l(2)k04809, mmp1, DmelCG4859, CG4859, MMP1, Mmp1a, Mmp1 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Human (80), Rat (Rattus) (42), Mouse (Murine) (41), Dog (Canine) (37), Cow (Bovine) (36), Horse (Equine) (31), Rabbit (31), Pig (Porcine) (17), Guinea Pig (15), Sheep (Ovine) (15), Zebrafish (Brachydanio rerio) (3), Chicken (2)
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Flow Cytometry (FACS) (56), Immunofluorescence (IF) (55), Western Blotting (WB) (42), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23), ELISA (17), Immunoprecipitation (IP) (15), Enzyme Immunoassay (EIA) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunohistochemistry (IHC) (6), ELISA (Detection) (2), Immunoelectron Microscopy (IEM) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (EM) (1)
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| Catalog no. |
ABIN459617 |
| Quantity |
100µg (1 mg/ml) |
| Price |
743.71 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Alternative name
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MMP-1
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Format
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Liquid
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Description
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The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression
Synonyms: MAP2K6, EC 2.7.12.2, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3
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Specificity
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MMP-1 (H440) pAb detects endogenous levels of MMP-1 protein.
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Molecular Weight
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54 kDa
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Application Notes
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WB: 1:500-1:1000 IHC: 1:50-1:200 IF: 1:50-1:200
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE).
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Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Buffer
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1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1)", type "Antibodies"
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Hosts
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Rabbit (84), Mouse (12), Sheep (2)
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Reactivities
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Human (80), Rat (Rattus) (42), Mouse (Murine) (41), Dog (Canine) (37), Cow (Bovine) (36), Horse (Equine) (31), Rabbit (31), Pig (Porcine) (17), Guinea Pig (15), Sheep (Ovine) (15), Zebrafish (Brachydanio rerio) (3), Chicken (2)
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Applications
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Flow Cytometry (FACS) (56), Immunofluorescence (IF) (55), Western Blotting (WB) (42), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23), ELISA (17), Immunoprecipitation (IP) (15), Enzyme Immunoassay (EIA) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunohistochemistry (IHC) (6), ELISA (Detection) (2), Immunoelectron Microscopy (IEM) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (EM) (1)
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Conjugates
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HRP (5), Biotin (4), Alexa Flour 488 (3), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), FITC (3), Gold (3), PE (3), PE,Cy3 (3), PE,Cy5 (3), PE,Cy5.5 (3), PE,Cy7 (3), RBITC (3)
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Epitopes
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hinge (3), Cleaved-Phe100 (1)
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