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Chemokine (C-C Motif) Receptor 5 (CCR5) antibody
| Antigen | Chemokine (C-C Motif) Receptor 5 (CCR5) |
| Synonyms | CKR5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5, FLJ78003, Ckr5, Cmkbr5, CCR5, CCR1-L, GPCR, MGC137803, CCR-5, AM4-7, CCR2, CCR5-L |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human |
| Application |
Alternatives Western Blotting (WB)
|
| Catalog no. | ABIN459775 |
| Quantity | 100µg (1 mg/ml) (Variants) |
| Price | 743.71 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | CCR5 |
| Format | Liquid |
| Description |
The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer. Synonyms: CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CHEMR13, CKR-5, CKR5, CMKBR5 |
| Specificity | CCR5 (T343) pAb detects endogenous levels of CCR5 protein. |
| Molecular Weight | 50 kDa |
Application Details
| Application Notes | WB: 1:500-1:1000 |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE). |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Buffer | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Chemokine (C-C Motif) Receptor 5 (CCR5)", type "Antibodies"
