JAK3 antibody
| Antigen |
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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| Catalog no. |
ABIN460048 |
| Quantity |
100µg (1 mg/ml) (Variants) |
| Price |
743.71 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Format
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Liquid
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Description
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Jak3 (Janus Kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Synonyms: JAK3, EC 2.7.10.2, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
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Specificity
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JAK3 (I781) pAb detects endogenous levels of JAK3 protein.
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Molecular Weight
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125.0 kDa
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Application Notes
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WB: 1:500-1:1000 IHC: 1:50-1:200 IF:1:50-1:200
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE).
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Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Buffer
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1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "JAK3", type "Antibodies"
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Hosts
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Mouse (6), Rabbit (4)
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Reactivities
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Human (9), Mouse (Murine) (4), Rat (Rattus) (2)
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Applications
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Western Blotting (WB) (6), ELISA (5), Immunofluorescence (IF) (3), Immunohistochemistry (IHC) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Flow Cytometry (FACS) (1), Immunocytochemistry (ICC) (1)
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Epitopes
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Ab-785 (1), pTyr785 (1)
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