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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) antibody

Antigen

C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
Synonyms ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, Abl, c-Abl, AI325092, MGC117749, E430008G22Rik, ABL1, ARG, ABLL, FLJ22224, FLJ31718, FLJ41441, Arg, Abll, AA536808, MGC169395, ABL2, CABL, cb272
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Catalog no. ABIN460546
Quantity 100µg  (1 mg/ml)  (Variants)
Price 743.71 $   Plus shipping costs $35.00
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anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) antibody

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) antibody (2)

Additional Information
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Alternative name c-Abl
Format Liquid
Description The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9,22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.
Synonyms: ABL1, ABL, C-ABL, EC 2.7.10.2, JTK7, P150, V-ABL
Specificity C-Abl (E883) pAb detects endogenous levels of c-Abl protein.
Molecular Weight 123 kDa

Application Details
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Application Notes WB: 1:500-1:1000 IHC: 1:50-1:200 IF: 1:50-1:200
Concentration 1 mg/ml
Purity > 95% (by SDS-PAGE).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Alternatives
Application Details Images Secondary Antibodies Variants back to top

Alternatives for antigen "C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)", type "Antibodies"
Hosts Rabbit (84), Mouse (10)
Reactivities Human (88), Mouse (Murine) (39), Rat (Rattus) (26), Cow (Bovine) (15), Dog (Canine) (15), Horse (Equine) (15), Pig (Porcine) (15), Rabbit (15)
Applications Western Blotting (WB) (54), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (31), Immunohistochemistry (IHC) (29), ELISA (24), Immunofluorescence (IF) (23), Enzyme Immunoassay (EIA) (18), Flow Cytometry (FACS) (13), Immunoprecipitation (IP) (10), Dot Blot (Dot) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunodiffusion (ID) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (4), Alexa Flour 488 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1)
Epitopes pTyr412 (10), Ab-412 (3), pTyr204 (3), pThr754 (2), pTyr251 (2), pTyr283 (2), C-Term (1), Center (1), N-Term H246 (1), N-Term K219 (1), Y251 (1), Y272 (1), Y276 (1), pSer588 (1), pTyr134 (1), pTyr245 (1), pTyr272 (1), pTyr276 (1), pY134 (1)