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CASP8 and FADD-Like Apoptosis Regulator (CFLAR) antibody
| Antigen | CASP8 and FADD-Like Apoptosis Regulator (CFLAR) |
| Synonyms |
CASH, FLIP, MRIT, CLARP, FLAME, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1, Cash, Flip, Gm9845, c-Flip, AI646576, AU021929, MGC103395, 2310024N18Rik, A430105C05Rik, ...
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| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human |
| Application |
Alternatives Immunohistochemistry (IHC)
|
| Catalog no. | ABIN460568 |
| Quantity | 100µg (1 mg/ml) (Variants) |
| Price | 743.71 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | c-FLIP |
| Format | Liquid |
| Description |
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2)are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP,respectively. The human homolog of viral FLIP has four splice variants known as FLIP alpha, Beta, gamma and kappa. These are FLICE inhibitory proteins also known as Casper, I-FLICE, FLAME-1, CASH, CLARP and Usurpin. They contain two death effector domains and one caspase domain. FLIP interacts with FADD, caspase-8 and 10 to inhibit apoptosis initiated by Fas, TNF-R1 and TRAIL-R. Synonyms: CFLAR, C-FLIP, C-FLIPL, C-FLIPR, C-FLIPS, CASH, CASP8AP1, CASPER, CLARP, FLAME, FLAME-1, FLIP, I-FLICE, MRIT, USURPIN |
| Specificity | C-FLIP (H204) pAb detects endogenous levels of c-FLIP protein. |
| Molecular Weight | 55 kDa |
| Synonyms | CASH, FLIP, MRIT, CLARP, FLAME, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1, Cash, Flip, Gm9845, c-Flip, AI646576, AU021929, MGC103395, 2310024N18Rik, A430105C05Rik, ENSMUSG00000072980, C-FLIP, MGC108616, Clarp1, CFLAR, DKFZp469E1815 |
Application Details
| Application Notes | IHC: 1:50-1:200 |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE). |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Buffer | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "CASP8 and FADD-Like Apoptosis Regulator (CFLAR)", type "Antibodies"
| Hosts | Rabbit (27), Mouse (10), Rat (2), Goat (1) |
| Reactivities | Human (37), Mouse (Murine) (14), Rat (Rattus) (7) |
| Applications | Western Blotting (WB) (39), Enzyme Immunoassay (EIA) (11), Immunofluorescence (IF) (10), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), ELISA (6), Immunoprecipitation (IP) (5), ELISA (Detection) (4), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Immunohistochemistry (IHC) (2) |
| Epitopes | C-Term (6), AA 1-376 (2), N-Term (2), AA 191-209 (1), AA 206-222 (1), AA 447-464 (1) |
