G Protein-Coupled Receptor 119 (GPR119) antibody

Antigen: G Protein-Coupled Receptor 119 (GPR119)

Synonyms: GPCR2, hGPCR2, MGC119957, GPR119

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunofluorescence (IF)

Catalog no.: ABIN460608

Additional Information

Alternative name: GPR119

Format: Liquid

Description: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intra cellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane- spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR119 is a 335 amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptor for lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insulin secretion from pancreatic  cells. GPR119 may participate in this insulin secretion, suggesting that it may be potential target for new anti-diabetic drugs.
Synonyms: GPR119, GPCR2, hGPCR2, MGC119957

Specificity: GPR119 (V227) pAb detects endogenous levels of GPR119 protein.

Molecular Weight: 37 kDa

Application Details

Application Notes: WB: 1:500-1:1000 IF: 1:50-1:200

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Restrictions: For Research Use only

Images

anti-G Protein-Coupled Receptor 119 (GPR119) antibody