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Lymphocyte-Specific Protein tyrosine Kinase (LCK) antibody
| Antigen | Lymphocyte-Specific Protein tyrosine Kinase (LCK) |
| Synonyms | YT16, p56lck, pp58lck, Lck1, Lcktkr, MGC136695, MGC194004, MGC194043, zgc:136695, LCK, MGC126900 |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB), Immunofluorescence (IF)
|
| Catalog no. | ABIN461051 |
| Quantity | 100µg (1 mg/ml) (Variants) |
| Price | 743.71 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | Lck |
| Format | Liquid |
| Description | Src is the human homolog of the v-Src gene of the Rous sarcoma virus, also called avian sarcoma virus or ASV. Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Src-family kinases contain an amino terminal cell membrane anchor followed by an SH3 domain and an SH2 domain that are involved in modular association and activation, respectively. Src-family kinases are normally maintained in an inactive state and can be activated transiently during cellular events such as mitosis. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes, such as mitogenesis, cytoskeletal organization and membrane trafficking. The Fyn and Lck Src family tyrosine kinases play a key role in T cell antigen receptor (TCR) signaling. The human Lck gene maps to chromosome 1p34.3 and encodes a 509 amino acid protein. |
| Specificity | Lck (L387) pAb detects endogenous levels of Lck protein. |
| Molecular Weight | 52.0 kDa |
Application Details
| Application Notes | WB: 1:500-1:1000 IF:1:50-1:200 |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE). |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Buffer | 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Lymphocyte-Specific Protein tyrosine Kinase (LCK)", type "Antibodies"
| Hosts | Rabbit (57), Mouse (29) |
| Reactivities | Human (74), Mouse (Murine) (42), Rat (Rattus) (29), Chicken (2) |
| Applications | Western Blotting (WB) (74), Immunoprecipitation (IP) (26), Flow Cytometry (FACS) (18), Immunofluorescence (IF) (18), ELISA (15), Enzyme Immunoassay (EIA) (11), Immunohistochemistry (IHC) (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (6), Functional Studies (Func) (5), Immunocytochemistry (ICC) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), ELISA (Detection) (1), Immunoelectron Microscopy (IEM) (1) |
| Conjugates | Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1) |
| Epitopes | pTyr505 (21), pTyr394 (4), C-Term (3), pTyr393 (3), N-Term (1), phospho (1) |
