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Epidermal Growth Factor Receptor (EGFR) antibody

Antigen

Epidermal Growth Factor Receptor (EGFR)
Synonyms
ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33,  ... show more
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Catalog no. ABIN461061
Quantity 100µg  (1 mg/ml)  (Variants)
Price 743.71 $   Plus shipping costs $35.00
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anti-Epidermal Growth Factor Receptor (EGFR) antibody

Additional Information
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Alternative name EGFR
Format Liquid
Description The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor alpha (TGFalpha), amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase.
Specificity EGFR (S1166) pAb detects endogenous levels of EGFR protein.
Molecular Weight 175 kDa
Synonyms ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33, EFG-R, EGF-R, EGFR, EK2-6, Egf, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, HD-33, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR1, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, pnt, top, top/DER, top/flb, DmelCG10079, CG10079, egfr, EGFR12, EGFR15, egfr1, Erbb2

Application Details
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Application Notes WB: 1:500-1:1000 IHC: 1:50-1:200
Concentration 1 mg/ml
Purity > 95% (by SDS-PAGE).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Alternatives
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Alternatives for antigen "Epidermal Growth Factor Receptor (EGFR)", type "Antibodies"
Hosts Rabbit (417), Mouse (167), Rat (8), Sheep (7), Goat (2)
Reactivities Human (580), Mouse (Murine) (251), Rat (Rattus) (226), Dog (Canine) (33), Rabbit (18), Pig (Porcine) (17), Cow (Bovine) (6), Chicken (5), Horse (Equine) (2), Sheep (Ovine) (2)
Applications Western Blotting (WB) (417), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (134), Immunoprecipitation (IP) (120), Enzyme Immunoassay (EIA) (113), Immunohistochemistry (IHC) (102), Immunofluorescence (IF) (98), ELISA (92), Flow Cytometry (FACS) (90), Immunohistochemistry (Frozen Sections) (IHC (fro)) (43), Dot Blot (Dot) (28), Blocking Antibody (Inhibition) (16), Immunocytochemistry (ICC) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (4), Functional Studies (Func) (3), ELISA (Detection) (2), Immunoelectron Microscopy (IEM) (2), Neutralization (Neut) (2), Blocking Antibody (Inhibition) (1)
Conjugates Biotin (35), FITC (5), Alexa Fluor 488 (3), PE (3), Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), RBITC (2)
Epitopes pTyr1197 (19), C-Term (16), pTyr869 (15), pTyr1092 (14), pTyr1172 (13), pThr678 (12), pTyr1110 (12), pSer1070 (11), pThr693 (10), N-Term (5), pTyr1016 (4), pTyr1069 (4), AA 1-203 (2), AA 1140-1160 (2), AA 960-980 (2), Extracell. non Ligand binding Site (2), S695 (2), Y1125 (2), Y869 (2), Y998 (2), pSer1026 (2), pSer1071 (2), pSer1166 (2), pSer1190 (2), pSer695 (2), pSer768 (2), pTyr1125 (2), pTyr1173 (2), pTyr998 (2), AA 1189-1199 (1), AA 985-996 (1), Ab-1016 (1), Ab-1026 (1), Ab-1069 (1), Ab-1071 (1), Amino Acids 1165-1186 (1), External Domain (1), Extracellular non-ligand binding site (1), S1026 (1), S1070 (1), S1071 (1), S1166 (1), S1190 (1), S991 (1), T678 (1), TYR1173 (1), Y1016 (1), Y1069 (1), Y1092 (1), Y1110 (1), Y1172 (1), Y978 (1), extracellular ligand binding site (1), internal (1), pS1070 (1), pS768 (1), pSer1142 (1), pSer967 (1), pTyr1101 (1), pTyr1173, pTyr1248 (1), pTyr992 (1), pY1016 (1), pY1092 (1), pY1172 (1), prylated At Threonine 654 (1), prylated At Tyrosine 1045 (1), prylated At Tyrosine 1173 (1), prylated At Tyrosine 845 (1), prylated at Serine 1047 (1)

Variants
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Variants