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Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) antibody
| Antigen | Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) |
| Synonyms | FRAP, FRAP1, FRAP2, RAFT1, RAPT1, FLJ44809, flat, Frap1, AI327068, MGC118056, 2610315D21Rik, tor, fc22h08, wu:fc22h08, MTOR, TOR, RORG, RZRG, NR1F3, MGC129539, RZR-GAMMA |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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| Catalog no. | ABIN461066 |
| Quantity | 100µg (1 mg/ml) (Variants) |
| Price | 743.71 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | mTOR |
| Format | Liquid |
| Description | Regulatory associated protein of mTOR, also designated Raptor, is a binding partner for mammalian target of rapamycin kinase (mTOR), and is essential for mTOR signalling in vivo. Raptor binding to mTOR is critical for mTORcatalysed substrate phosphorylation of 4EBP1. The Raptor-mTOR complex is nutrient-sensitive and is important for a mechanism by which cells coordinate cell growth and size with changing environmental conditions. Raptor serves as a negative regulator of mTOR kinase activity under nutrient-deprived conditions and is an important component in the mTOR pathway. Raptor is highly expressed in skeletal muscle and to a lesser extent in brain, kidney, lung and placenta. |
| Specificity | MTOR (S2442) pAb detects endogenous levels of mTOR protein. |
| Molecular Weight | 289 kDa |
Application Details
| Application Notes | WB: 1:500-1:1000 IHC: 1:50-1:200 IF:1:50-1:200 |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE). |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Buffer | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Restrictions | For Research Use only |
Images
| anti-Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) antibody anti-Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) antibody (Image 2) |
Alternatives
Alternatives for antigen "Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1)", type "Antibodies"
| Hosts | Rabbit (82), Mouse (4) |
| Reactivities | Human (82), Mouse (Murine) (44), Rat (Rattus) (42), Dog (Canine) (2), Cow (Bovine) (1) |
| Applications | Western Blotting (WB) (51), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (29), Immunohistochemistry (IHC) (23), Enzyme Immunoassay (EIA) (22), Immunofluorescence (IF) (19), ELISA (9), Dot Blot (Dot) (6), Immunoprecipitation (IP) (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2) |
| Epitopes | pSer2448 (12), C-Term (3), N-Term (3), S2481 (2), pSer2481 (2), AA 2440-2457 (1), T2446 (1), pS2448 (1), pT2446 (1), pThr2446 (1) |
