PDGFR beta (0) antibody
| Antigen |
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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| Catalog no. |
ABIN461072 |
| Quantity |
100µg (1 mg/ml) (Variants) |
| Price |
743.71 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Alternative name
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PDGFR-beta
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Format
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Liquid
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Description
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Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.
Synonyms: PDGFRB, CD140B, EC 2.7.10.1, JTK12, PDGF-R-BETA, PDGFR, PDGFR1
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Specificity
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PDGFR-beta (K745) pAb detects endogenous levels of PDGFR-beta protein.
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Molecular Weight
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124 kDa
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Application Notes
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WB: 1:500-1:1000 IHC: 1:50-1:200 IF:1:50-1:200
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE).
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Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Buffer
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1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "PDGFR beta (0)", type "Antibodies"
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Hosts
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Rabbit (8), Mouse (1)
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Reactivities
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Human (9), Rat (Rattus) (8), Mouse (Murine) (4)
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Applications
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Immunohistochemistry (IHC) (7), Western Blotting (WB) (7), ELISA (4), Immunofluorescence (IF) (3), Flow Cytometry (FACS) (1), Immunoprecipitation (IP) (1), Neutralization (Neut) (1)
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Epitopes
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pTyr1021 (1), pTyr740 (1)
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