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B-Cell CLL/lymphoma 2 (BCL2) antibody

Antigen

B-Cell CLL/lymphoma 2 (BCL2)
Synonyms Bcl-2, bcl-2, BCL2
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Catalog no. ABIN461151
Quantity 100µg  (1 mg/ml)  (Variants)
Price 743.71 $   Plus shipping costs $35.00
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anti-B-Cell CLL/lymphoma 2 (BCL2) antibody

anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (2)

Additional Information
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Alternative name Bcl-2
Format Liquid
Description Apoptosis defines a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-2 is one among many key regulators of apoptosis which are essential for proper development, tissue homeostasis and protection against foreign pathogens. Human Bcl-2 is a 26 kD,a membraneassociated, anti-apoptotic oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xL, Mcl-1, Bcl-w and A1, or the death agonists Bax, Bak, Bik, Bad and BID. The anti-apoptotic function of Bcl-2 can also beregulated through proteolytic processing and phosphorylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane. Mutations in the Bcl-2 gene can contribute to cancers where normal physiological cell death mechanisms are compromised by deregulation of the antiapoptotic influence of Bcl-2.
Synonyms: IgG Fraction of Anti-Human Bcl-2 (Rabbit), BCL2
Specificity Bcl-2 (S50) pAb detects endogenous levels of Bcl-2 protein.
Molecular Weight 26 kDa

Application Details
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Application Notes WB: 1:500-1:1000 IHC: 1:50-1:200 IF: 1:50-1:200
Concentration 1 mg/ml
Purity > 95% (by SDS-PAGE).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Alternatives
Application Details Images Secondary Antibodies Variants back to top

Alternatives for antigen "B-Cell CLL/lymphoma 2 (BCL2)", type "Antibodies"
Hosts Rabbit (123), Mouse (27), Goat (4), Sheep (3)
Reactivities Human (145), Mouse (Murine) (57), Rat (Rattus) (55), Cow (Bovine) (37), Dog (Canine) (37), Pig (Porcine) (34), Rabbit (21), Chicken (18), Horse (Equine) (18), Cat (Feline) (2), Sheep (Ovine) (2)
Applications Western Blotting (WB) (96), Immunofluorescence (IF) (65), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (47), Flow Cytometry (FACS) (43), Immunoprecipitation (IP) (36), Immunohistochemistry (IHC) (34), Immunohistochemistry (Frozen Sections) (IHC (fro)) (27), ELISA (24), Enzyme Immunoassay (EIA) (16), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (4), Immunocytochemistry (ICC) (3), Dot Blot (Dot) (2), Immunoelectron Microscopy (IEM) (2)
Conjugates PE (3), Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), RBITC (2)
Epitopes pSer70 (5), pThr56 (5), BH3 Domain Specific (1)