Add to Basket
Order hotline:
 |
+1 404 474 4654 |
 |
+1 888 205 9894 (TF) |
PDGFR beta (0) antibody
| Antigen | PDGFR beta (0) |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
|
| Catalog no. | ABIN461611 |
| Quantity | 100µg (1 mg/ml) (Variants) |
| Price | 743.71 $ Plus shipping costs $35.00 |
| Shipping to |
|
| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | PDGFR beta |
| Format | Liquid |
| Description |
Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and gliaderived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PDGF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-alpha and -beta, which are endowed with protein tyrosine kinase domains. PDGFR-alpha can bind to both A and B subunits of PDGF, while PDGFR-beta can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two alpha receptors, PDGF-AB induces dimerization of alphaalpha and alphabeta and PDGF-BB induces the formation of three types of dimers, alphaalpha, alphabeta and betabeta. The genes encoding PDGFR-alpha and -beta map to human chromosome 4q11-q13 and 5q31-32, respectively. The expressed alpha and beta receptor proteins migrate at 170 and 180 kDa, respectively, by SDS-PAGE. Translocation of the PDGFR-beta gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. Synonyms: PDGFRB, CD140B, EC 2.7.10.1, JTK12, PDGF-R-BETA, PDGFR, PDGFR1 |
| Specificity | PDGFR beta (D757) pAb detects endogenous levels of PDGFR beta protein. |
| Molecular Weight | 170 kDa |
Application Details
| Application Notes | WB: 1:500-1:1000 IHC: 1:50-1:200 |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE). |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Buffer | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "PDGFR beta (0)", type "Antibodies"
| Hosts | Rabbit (8), Mouse (1) |
| Reactivities | Human (9), Rat (Rattus) (8), Mouse (Murine) (4) |
| Applications | Immunohistochemistry (IHC) (7), Western Blotting (WB) (7), ELISA (4), Immunofluorescence (IF) (4), Flow Cytometry (FACS) (1), Immunoprecipitation (IP) (1), Neutralization (Neut) (1) |
| Epitopes | pTyr1021 (1), pTyr740 (1) |
