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Amyloid beta (A4) Precursor Protein (APP) antibody

Antigen

Amyloid beta (A4) Precursor Protein (APP)

Synonyms APP, APP-like, APPL, Abeta, BcDNA:GH04413, EG:65F1.5, DmelCG7727, CG7727, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma
Clonality Polyclonal
Host
Alternatives

Rabbit

Reactivity
Alternatives

Human

Application
Alternatives Immunohistochemistry (IHC)
Catalog no. ABIN461633
Quantity 100µg  (1 mg/ml)  (Variants)
Price 743.71 $   Plus shipping costs $35.00
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Availability Ships within 7 to 10 Business Days

Additional Information

Alternative name beta Amyloid A4
Format Liquid
Description The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.
Synonyms: APP, A4, AAA, ABETA, ABPP, AD1, APPI, CTFGAMMA, CVAP, PN-II, PN2, PREA4
Specificity Beta Amyloid A4 (H749) pAb detects endogenous levels of beta Amyloid A4 protein.

Application Details

Application Notes IHC: 1:50-1:200
Concentration 1 mg/ml
Purity > 95% (by SDS-PAGE).
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Alternatives

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts Rabbit (133), Mouse (62), Goat (22)
Reactivities Human (168), Mouse (Murine) (56), Rat (Rattus) (37), Dog (Canine) (5), Monkey (5), Chicken (4), Cow (Bovine) (4), Pig (Porcine) (3), Guinea Pig (2), Rabbit (2), Primate (1)
Applications Western Blotting (WB) (189), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (55), ELISA (47), Enzyme Immunoassay (EIA) (47), Immunofluorescence (IF) (38), Immunohistochemistry (IHC) (35), Flow Cytometry (FACS) (18), Immunoprecipitation (IP) (18), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), Dot Blot (Dot) (6), Immunocytochemistry (ICC) (3), Radioimmunoassay (RIA) (2)
Conjugates FITC (1)
Epitopes variant 1 (10), C-Term (9), N-Term (5), p668 (4), AA 653-662 (3), pThr668 (3), AA 292-312 (2), AA 44-63 (2), AA 671-685 (2), AA 747-761 (2), Ab-730 (2), pSer198 (2), pSer730 (2), pTyr756 (2), AA 1-14 (1), AA 350-450 (1), C-Term D672 (1), Carboxyl Terminal amino acids 737-751 (1), KPI Domain (1), Y756 (1), all isoforms (1), pS198 (1), pS730 (1), pThr743/668 (1)

Variants

Variants