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V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) antibody
| Antigen | V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) |
| Synonyms | Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, mKIAA3023, NEU, NGL, TKR1, CD340, HER-2/neu |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus) |
| Application |
Alternatives Immunohistochemistry (IHC)
|
| Catalog no. | ABIN461658 |
| Quantity | 100µg (1 mg/ml) (Variants) |
| Price | 743.71 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | HER2 |
| Format | Liquid |
| Description |
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy-terminus of ErbB-3. Synonyms: EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen, HER2, HER2, NEU, NGL |
| Specificity | HER2 (V1254) pAb detects endogenous levels of HER2 protein. |
Application Details
| Application Notes | IHC: 1:50-1:200 |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE). |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Buffer | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Restrictions | For Research Use only |
Images
| anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) antibody |
Alternatives
Alternatives for antigen "V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)", type "Antibodies"
| Hosts | Rabbit (119), Mouse (58), Rat (4), Sheep (3), Chicken (2) |
| Reactivities | Human (172), Rat (Rattus) (72), Mouse (Murine) (70), Monkey (7), Dog (Canine) (6) |
| Applications | Western Blotting (WB) (143), Immunofluorescence (IF) (71), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (67), Immunohistochemistry (IHC) (58), Enzyme Immunoassay (EIA) (35), Immunoprecipitation (IP) (20), Immunohistochemistry (Frozen Sections) (IHC (fro)) (15), ELISA (14), Flow Cytometry (FACS) (13), Functional Studies (Func) (4), Dot Blot (Dot) (1), Radioimmunoassay (RIA) (1) |
| Conjugates | Biotin (3), FITC (1) |
| Epitopes | pTyr1248 (16), pTyr877 (10), Ab-1221/1222 (5), pTyr1112 (5), pTyr1221/Tyr1222 (5), C-Term (4), pTyr1221/1222 (3), AA 1240-1260 (2), pSer1113 (2), pThr686 (2), AA 1243-1255 (1), AA 153-433 (1), N-Term (1), pTyr1139 (1) |
