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Antibodies
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anti-Janus Kinase 1 (JAK1) antibody
Janus Kinase 1 (JAK1) antibody
| Antigen |
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| Synonyms |
JTK3, JAK1A, JAK1B, AA960307, MGC37919, C130039L05Rik, MAPK8, JNK, JNK1, JAK1, jak1 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN461663 |
| Quantity |
100µg (1 mg/ml) (Variants) |
| Price |
743.71 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Alternative name
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JAK1
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Format
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Liquid
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Description
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Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
Synonyms: Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A
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Specificity
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JAK1 (D1028) pAb detects endogenous levels of JAK1 protein.
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Application Notes
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IHC: 1:50-1:200
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE).
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Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Buffer
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1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "Janus Kinase 1 (JAK1)", type "Antibodies"
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Hosts
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Rabbit (50), Mouse (2)
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Reactivities
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Human (50), Mouse (Murine) (42), Rat (Rattus) (41), Dog (Canine) (17), Pig (Porcine) (15), Cow (Bovine) (2), Zebrafish (Brachydanio rerio) (2), Chicken (1), Sheep (Ovine) (1)
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Applications
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Western Blotting (WB) (29), Immunofluorescence (IF) (19), Flow Cytometry (FACS) (18), Immunohistochemistry (IHC) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (13), ELISA (7), Enzyme Immunoassay (EIA) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitopes
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pTyr1022 (11), Ab-1022 (5)
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Alternatives 
