ACE antibody

Antigen: ACE

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN471163

Additional Information

Swiss-Prot: P12821

Immunogen: Purified protein, Denatured human kidney CD143 (Angiotensin converting enzyme).

Isotype: IgG1  (Matching secondary antibodies)

Description: Gene: ACE, Standard Gene Symbol: ACE, Family: Protease, Subfamily: Metallopeptidase M2, Synonyms: ACE, ACE1, Angiotensin Converting Enzyme 1, ANGIOTENSIN I-CONVERTING ENZYME, Angiotensin-converting enzyme, CD143, DCP, DCP1, DIPEPTIDYL CARBOXYPEPTIDASE, DIPEPTIDYL CARBOXYPEPTIDASE 1, KININASE II, MGC26566, MVCD3, Peptidyl-dipeptidase A

Specificity: Recognizes human CD143, also know as angiotensin-converting enzyme (ACE). CD143 exists in two forms, a 170kD somatic form and a 90kD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. Study of CD143 may be relevant to fertility (especially sperm-egg interactions), atherosclerosis and in drug targeting to the lung. This clone recognizes denatured ACE, binding to an epitope in the C domain and has been reported to be active in Western blotting. Species cross-reactivity: Human, monkey, rabbit, bovine, canine, feline, guinea pig, rat, mouse. Predicted Reactivities: Cow (Bovine),Cat (Feline),Dog (Canine),Guinea Pig,Monkey,Mouse (Murine),Rabbit,Rat (Rattus).

Application Details

Application Notes: ELISA, IHC-P, WB (1:50 - 1:100)

Purification: Supernatant

Buffer: Tissue Culture Supernatant. Supplied as a liquid, 0.1% sodium azide.

Storage: Long term: -20°C, Short term: +4°C

Restrictions: For Research Use only