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Details for Product No. ABIN486853

NK2 Homeobox 5 (NKX2-5) (N-Term) antibody

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Antigen
Synonyms NKX2.5, CHNG5, CSX, CSX1, HLHS2, NKX2E, NKX4-1, VSD3, Csx, Nkx2.5, NKX2-5, Nkx2-5, csx, csx1, nkx2e, nkx2.5, tinman, Nkx-2.5, XNkx2-5, XNkx-2.5
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN486853
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-Nkx2-5 antibody: synthetic peptide directed towards the n terminal of human Nkx2-5
Sequence ELGRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKK ELCALQKAVE
Predicted Reactivity Human : 100%, Mouse : 92%, Rat : 92%, Guinea pig : 91%, Bovine : 84%, Dog : 84%, Rabbit : 76%
Characteristics This is a rabbit polyclonal antibody against NKX2-5. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name Nkx2-5
Background Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development. It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995 [PubMed 7665173]). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.
Molecular Weight 35kDa
Gene ID 1482
NCBI Accession NP_004378, NM_004387
UniProt P52952
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-Nkx2-5 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Nagel, Meyer, Quentmeier et al.: "MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines." in: Leukemia, Vol. 22, Issue 3, pp. 600-7, 2008 (PubMed).

Alternatives for antigen "NK2 Homeobox 5 (NKX2-5)", type "Antibodies"
Hosts (27), (18), (4)
Reactivities (46), (20), (16), (14), (14), (11), (2), (1), (1), (1), (1), (1), (1)
Applications (38), (25), (9), (5), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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