OPTN antibody (N-Term)

Catalog No. ABIN486920

Product Details anti-OPTN Antibody

Target: OPTN (Optineurin (OPTN))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPTN antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LSAWTEKQKE ERQFFEIQSK EAKERLMALS HENEKLKEEL GKLKGKSERS

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against OPTN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human OPTN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 577 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for OPTN

Target: OPTN (Optineurin (OPTN))

Alternative Name: OPTN (OPTN Products)

Synonyms: nrp antibody, fip2 antibody, hip7 antibody, hypl antibody, glc1e antibody, tfiiia-intp antibody, ALS12 antibody, FIP2 antibody, GLC1E antibody, HIP7 antibody, HYPL antibody, NRP antibody, TFIIIA-INTP antibody, Fip2 antibody, 4930441O07Rik antibody, fj52f04 antibody, si:ch211-240l19.3 antibody, wu:fj52f04 antibody, zgc:66386 antibody, zgc:77868 antibody, optineurin antibody, optineurin L homeolog antibody, OPTN antibody, optn antibody, Optn antibody, optn.L antibody

Background: OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, ALS12
Protein Interaction Partner: RAB10, TNIP1, OPTN, DAZAP2, CDC23, UBC, PARK2, ZNF670, ZNF329, TBC1D15, ZNF398, CCDC53, MAP1LC3A, TBC1D17, HACE1, RAB25, RAB11B, SQSTM1, RAB11A, Rab8a, Tfrc, BRE, FAM178A, UQCRQ, GNAS, RAB12, EPS15, RAB14, MAP1LC3B, PIAS4, RNF11, RIPK1, TNFRSF1A, TNF, HTT
Protein Size: 577

Molecular Weight: 66 kDa

Gene ID: 10133

NCBI Accession: NM_001008213, NP_001008214

UniProt: Q96CV9

Pathways: M Phase