anti-SUFUH antibody (Suppressor of Fused Homolog (Drosophila)) (N-Term)

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Antigen
Synonyms CG6054, Dmel\\CG6054, SU(FU), SUFU, Su(Fu), SuFu, Sufu, su(fu), sufu, Xsufu, sufuh, sufuxl, PRO1280, SUFUH, SUFUXL, Su(fu), dre, fi39e05, wu:fi39e05, 2810026F04Rik, b2b273Clo
Alternatives
Epitope
N-Term
(10), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Fruit Fly (Drosophila melanogaster), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(48), (20), (20), (6), (3), (2), (2), (2), (2), (2), (1)
Host
Rabbit
(48), (5), (3)
Clonality
Polyclonal
Conjugate
This SUFUH antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(32), (12), (10), (9), (7), (2), (2), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human SUFU
Sequence HAIYGECRRL YPDQPNPLQV TAIVKYWLGG PDPLDYVSMY RNVGSPSANI
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 90 %, African clawed frog : 80 %, Chicken : 80 %
Characteristics This is a rabbit polyclonal antibody against SUFU. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SUFU (SUFUH Antibody Abstract)
Background SUFU is a component of the Sonic hedgehog (SHH, MIM 600725)/Patched (PTCH, MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes.SUFU encodes a component of the sonic hedgehog (SHH, MIM 600725)/patched (PTCH, MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945, BCNS, MIM 109400, and GCPS, MIM 175700).
Molecular Weight 54 kDa
Gene ID 51684
NCBI Accession NM_016169, NP_057253
UniProt Q9UMX1
Pathways Hedgehog Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 484 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-SUFUH antibody (Suppressor of Fused Homolog (Drosophila)) (N-Term) (ABIN487004) WB Suggested Anti-SUFU Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Background publications Lee, Deng, Wang et al.: "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 51, pp. 20350-5, 2007 (PubMed).

Catalog No. ABIN487004
$289.00
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