Toll-Like Receptor 9 (TLR9) (N-Term) antibody

Details for Product No. ABIN487042
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Antigen
Synonyms CD289
Epitope
N-Term
(30), (16), (10), (7), (7), (7), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Pig (Porcine), Human
(153), (82), (35), (15), (14), (12), (2), (1), (1)
Host
Rabbit
(103), (52), (16), (8), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(17), (12), (8), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(145), (77), (60), (48), (34), (32), (21), (10), (6), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN487042
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TLR9
Sequence VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN
Predicted Reactivity Bovine : 100 %, Goat : 100 %, Horse : 100 %, Human : 100 %, Pig : 100 %, Sheep : 100 %, Mouse : 80 %, Rabbit : 80 %, Rat : 80 %, Dog : 80 %
Characteristics This is a rabbit polyclonal antibody against TLR9. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TLR9
Background TLR9 participates in the innate immune response to microbial agents. TLR9 detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. TLR9 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Molecular Weight 113 kDa
Gene ID 54106
NCBI Accession NP_059138, NM_017442
UniProt Q9NR96
Research Area Immunology, Innate Immunity, Signaling, Inflammation
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1032 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Toll-Like Receptor 9 (TLR9) (N-Term) antibody WB Suggested Anti-TLR9 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: ACHN cell lysate
Background publications Ramirez-Ortiz, Specht, Wang et al.: "Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA." in: Infection and immunity, Vol. 76, Issue 5, pp. 2123-9, 2008 (PubMed).

Validation Images
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