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MLL4 antibody (C-Term)

MLL4 Reactivity: Human, Mouse, Rat IHC (p), EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN488001
  • Target See all MLL4 Antibodies
    MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))
    Binding Specificity
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 14
    • 12
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 12
    • 2
    • 1
    Goat
    Clonality
    • 13
    • 2
    Polyclonal
    Conjugate
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MLL4 antibody is un-conjugated
    Application
    • 6
    • 5
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to MLL4.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogen
    Peptide with sequence CNCGAKRCRRFLN, from the C Terminus of the protein sequence according to NP_055542.
    Top Product
    Discover our top product MLL4 Primary Antibody
  • Application Notes
    Peptide ELISA: 1/128000. Western blot: Preliminary experiments gave no signal but low background in Human Heartlysates at up to 1 μg/mL. However this used our routine western blotting protocol which wewould not expect to reliably detect proteins as large as the predicted size of approx.312KDa according to NP_055542. Immunohistochemistry on paraffin sections: Human Testis shows cytoplasm staining ofspermatids. Recommended concentration: 5 - 10 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))
    Alternative Name
    MLL4 (MLL4 Products)
    Synonyms
    HRX2 antibody, MLL1B antibody, MLL2 antibody, MLL4 antibody, TRX2 antibody, WBP7 antibody, 2610014H22Rik antibody, Mll2 antibody, Wbp7 antibody, mKIAA0304 antibody, ALR antibody, BC032281 antibody, BC058659 antibody, C430014K11Rik antibody, KMT2B antibody, Mll4 antibody, RGD1308331 antibody, lysine methyltransferase 2B antibody, lysine (K)-specific methyltransferase 2B antibody, lysine (K)-specific methyltransferase 2D antibody, KMT2B antibody, Kmt2b antibody, Kmt2d antibody
    Background
    KMT2D / MLL4 contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This protein is ubiquitously expressed in adult tissues where it possibly acts as a transcriptional regulatory factor. It is also expressed in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced gene transcripts encoding distinct isoforms have been reported, however, the full length nature of the shorter transcript is not known.Synonyms: HRX2, Histone-lysine N-methyltransferase MLL4, KIAA0304, KMT2D, Lysine N-methyltransferase 2D, MLL2, Myeloid/lymphoid or mixed-lineage leukemia protein 4, TRX2, Trithorax homolog 2, WBP7, WW domain-binding protein 7
    Gene ID
    9757
    NCBI Accession
    NP_055542
    UniProt
    Q9UMN6
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Warburg Effect
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