GNA15 antibody

Catalog No. ABIN488048

Product Details anti-GNA15 Antibody

Target: GNA15 (Guanine Nucleotide Binding Protein (G Protein), alpha 15 (Gq Class) (GNA15))

Reactivity: Human, Mouse, Rat, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNA15 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody detects GA15 in samples from Human, Mouse, Rat, and Rabbit origins. It also detects GA16 from samples of Human origin.

Purification: Affinity Chromatography.

Immunogen: Synthetic peptide surrounding amino acid 356 of Human G Protein Alpha 15

Application Details

Application Notes: Western blotting (0.5-4 μg/mL). From Researcher's feedback, the antibody can be used in Immunohistochemistry (5-20 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS ( pH 7.2) containing 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal as preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for GNA15

Target: GNA15 (Guanine Nucleotide Binding Protein (G Protein), alpha 15 (Gq Class) (GNA15))

Alternative Name: G Protein alpha 15 (GNA15 Products)

Synonyms: GNA16 antibody, G[a]15 antibody, Galpha15 antibody, G protein subunit alpha 15 antibody, guanine nucleotide binding protein (G protein), alpha 15 (Gq class) antibody, guanine nucleotide binding protein, alpha 15 antibody, GNA15 antibody, Gna15 antibody

Background: G Protein alpha 16 (GA16) is the only heterotrimeric G protein with a restricted expression pattern in hematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of GA16. The G protein is known to couple a large number of G protein-coupled receptors to PLC-beta and can lead to production of the secondary messengers diacylglycerol and inositol phosphates. Targeted deletion of GA15, a mouse orthologue of human GA16, causes reduced C5α receptor signaling. GA16 serves as a marker, in addition to CD34, for hematopoietic progenitor cells.Synonyms: G alpha-15, GNA15, GNA16, Guanine nucleotide-binding protein subunit alpha-15

Gene ID: 2769

NCBI Accession: NP_002059

UniProt: P30679