Chemokine (C-C Motif) Receptor 1 (CCR1) (AA 1-24) antibody

Antigen: Chemokine (C-C Motif) Receptor 1 (CCR1)

Synonyms: CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1

Epitope: AA 1-24

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN488057

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CMKBR1, CMKR1, SCYAR1,HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP1 alphaReceptor, RANTES-R

Alternative name: CD191 / CCR1

Gene ID: 1230

Swiss-Prot: P32246

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and24 of CCR1.

Cross-Reactivity: Human

Description: This gene encodes a member of the beta chemokine receptor family, which is predicted tobe a seven transmembrane protein similar to G protein-coupled receptors. The ligands ofthis receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated onactivation normal T expressed and secreted protein (RANTES), monocyte chemoattractantprotein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines andtheir receptors mediated signal transduction are critical for the recruitment of effectorimmune cells to the site of inflammation. Knockout studies of the mouse homologsuggested the roles of this gene in host protection from inflammatory response, andsusceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 andCCXCR1, are found to form a gene cluster on chromosome 3p.

Specificity: Recognizes Chemokine (C-C motif) Receptor 1 (CD191/CCR1). Species Reactivity: Tested: Human.

Application Details

Application Notes: Western blotting: 1/500-1/3000. Immunohistochemistry on Paraffin Sections: 1/100-1/500. Positive Controls: 293T, A431, H1299, HepG2, RajiOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Aff - Purified

Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7) containing 0.01% Thimerosal asa preservative.

Storage: Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only