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Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) antibody

Details for Product No. ABIN488095, Supplier: Login to see
Antigen
  • cb358
  • wu:fc55h08
  • UCHL1
  • UCH-L1
  • park5
  • pgp9.5
  • uch-l1
  • MGC132191
  • uchl1
  • AW822034
  • C88048
  • PGP 9.5
  • PGP9.5
  • R75593
  • UCHL-1
  • gad
  • PARK5
  • PGP95
  • Uch-L1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
303
91
77
23
16
11
8
5
4
4
4
3
2
1
1
Host
Chicken
165
103
35
17
8
4
Clonality
Polyclonal
Conjugate
Un-conjugated
11
11
8
7
7
7
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
258
130
88
66
46
18
14
12
10
9
6
3
3
Supplier
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Immunogen Full length recombinant Human UCHL1.
Isotype Ig
Specificity Recognizes UCHL1/PGP9.5.
Alternative Name UCHL1 / PGP9.5 (UCHL1 Antibody Abstract)
Background Ubiquitin C-terminal hydrolase 1 is also known as as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It is involved in the regulation of the ubiquitin-mediated protein degradation pathway which is very important because many disease states are associated with defects in this pathway. Mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, antibodies to UCHL1 can be used to identify neurons in histological sections and in tissue culture. The great abundance of this protein in neurons means that it is released from neurons in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.Synonyms: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1
Gene ID 7345
NCBI Accession NP_004172
UniProt P09936
Research Area Tags/Labels, Cell/Tissue Markers
Pathways
Application Notes Western Blot: 1/2,000. Immunofluorescence: 1/200. Immunocytochemistry: 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 50 % Glycerol and 0.01 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Background publications Liu, Fallon, Lashuel et al.: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, 2002 (PubMed).