Matrix Metalloproteinase 2 (MMP2) (C-Term), (AA 475-490) antibody

Details for Product No. ABIN488098
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Antigen
Synonyms
CLG4, MONA, CLG4A, TBE-1, MMP-II, GelA, Clg4a, MMP-2, 2-MMP, CG1794, DM2-MMP, Dm2-MMP, Dmel\\CG1794, MMP2, anon-WO0118547.84, dm-2MMP, dmmp2, l(2)02353, mmp2, wu:fa99h12, wu:fk89d01, fgmmp-2, Mmp-2, L ... show more
CLG4, MONA, CLG4A, TBE-1, MMP-II, GelA, Clg4a, MMP-2, 2-MMP, CG1794, DM2-MMP, Dm2-MMP, Dmel\\CG1794, MMP2, anon-WO0118547.84, dm-2MMP, dmmp2, l(2)02353, mmp2, wu:fa99h12, wu:fk89d01, fgmmp-2, Mmp-2, LOC100135793 show less
Epitope
C-Term, AA 475-490
(14), (9), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(224), (102), (91), (42), (41), (20), (13), (4), (2), (2), (1), (1), (1)
Host
Rabbit
(150), (94), (3), (2), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(17), (9), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(190), (102), (92), (51), (42), (32), (30), (29), (23), (21), (4), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN488098
Quantity 0.1 mL
Price
368.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen Synthetic peptide KLH conjugated corresponding to C-terminal (aa 475-490) of Human MMP2.
Isotype IgG
Specificity Recognizes Matrix Metalloproteinase-2 (MMP2).
Alternative Name MMP-2
Background MMP2 is a member of the matrix metalloproteinase (MMP) enzyme family and is involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP2 degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome, Torg syndrome and nodulosis-arthropathy-osteolysis syndrome. MMP2 is secreted as an inactive proenzyme/zymogen which is activated when cleaved by extracellular proteinases. The proform has a molecular weight of 72kDa and the active form 62kDa.
Alternate names: 72 kDa gelatinase, 72 kDa type IV collagenase, CLG4A, Gelatinase A, MMP2, Matrix metalloproteinase-2, TBE-1
Gene ID 4313
NCBI Accession NP_001121363
UniProt P08253
Research Area Extracellular Matrix
Application Notes Western Blot: 1/1,000. Immunofluorescence: 1/100. Immunocytochemistry: 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 50% Glycerol and 0.01% Sodium Azide.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Collier, Wilhelm, Eisen et al.: "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen." in: The Journal of biological chemistry, Vol. 263, Issue 14, pp. 6579-87, 1988 (PubMed).

Hosts (150), (94), (3), (2), (1), (1), (1)
Reactivities (224), (102), (91), (42), (41), (20), (13), (4), (2), (2), (1), (1), (1)
Applications (190), (102), (92), (51), (42), (32), (30), (29), (23), (21), (4), (1), (1), (1), (1), (1)
Conjugates (17), (9), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (14), (9), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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