RAMP1 antibody (AA 84-148)

Catalog No. ABIN488104

Product Details anti-RAMP1 Antibody

Target: RAMP1 (Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1))

Binding Specificity: AA 84-148

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAMP1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Recognizes RAMP1
Cellular Localization: Membrane, Single-pass type I membrane protein.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Antigen-Affinity Chromatography.

Immunogen: Amino Acids 84-148 of Human RAMP1

Application Details

Application Notes: Western blot. Positive Controls: HepG2
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.87 mg/mL

Buffer: 0.1 M Tris, 0.1 M Glycine, 10 % Glycerol ( pH 7) containing 0.01 % Thimerosal as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted at (in aliquots) at -20 °C.

Target Details for RAMP1

Target: RAMP1 (Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1))

Alternative Name: RAMP1 (RAMP1 Products)

Synonyms: RAMP1 antibody, MGC147096 antibody, 9130218E19Rik antibody, receptor activity modifying protein 1 antibody, receptor (G protein-coupled) activity modifying protein 1 antibody, receptor (calcitonin) activity modifying protein 1 antibody, RAMP1 antibody, ramp1 antibody, Ramp1 antibody

Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.Synonyms: CRLR activity-modifying protein 1, Calcitonin-receptor-like receptor activity-modifying protein 1, RAMP-1, Receptor activity-modifying protein 1

Molecular Weight: 17 kDa

Gene ID: 10267, 9606

UniProt: O60894

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process