RAMP2 antibody (AA 111-175)

Catalog No. ABIN488105

Product Details anti-RAMP2 Antibody

Target: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Binding Specificity: AA 111-175

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAMP2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Recognizes RAMP2
Cellular Localization: Membrane, Single-pass type I membrane protein.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Antigen-Affinity Chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 111 and 175 of Human RAMP2

Application Details

Application Notes: Western blot: 1/500-1/3000Positive Controls: Molt-4, Raji.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.1 M Tris, 0.1 M Glycine, 10 % Glycerol ( pH 7) containing 0.01 % Thimerosal as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted at (in aliquots) at -20 °C.

Target Details for RAMP2

Target: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Alternative Name: RAMP2 (RAMP2 Products)

Synonyms: RAMP2 antibody, zgc:174936 antibody, receptor activity modifying protein 2 antibody, receptor (G protein-coupled) activity modifying protein 2 antibody, receptor (calcitonin) activity modifying protein 2 antibody, RAMP2 antibody, ramp2 antibody, Ramp2 antibody

Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called Receptor (calcitonin) Activity Modifying Proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport Calcitonin-Receptor-like Receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.Synonyms: CRLR activity-modifying protein 2, Calcitonin-receptor-like receptor activity-modifying protein 2, Receptor activity-modifying protein 2

Molecular Weight: 20 kDa

Gene ID: 10266, 9606

UniProt: O60895

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling