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CDK6 antibody (Cyclin-Dependent Kinase 6)

Details for Product anti-CDK6 Antibody No. ABIN488121, Supplier: Log in to see
Antigen
  • CDK6
  • PLSTIRE
  • 5830411I20
  • AI504062
  • Crk2
  • cyclin-dependent kinase 6
  • CDK6
  • Cdk6
Alternatives
anti-Human CDK6 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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134
95
6
6
4
3
3
2
1
1
1
1
Host
Mouse
167
79
Clonality (Clone)
Monoclonal ()
Conjugate
This CDK6 antibody is un-conjugated
6
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunoprecipitation (IP), Western Blotting (WB)
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106
80
52
45
36
27
22
22
3
2
2
2
2
1
1
Options
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Immunogen Recombinant Cdk6 protein. Remarks: Hybridoma was established by fusion of mouse myeloma cell NS-2 with Balb/c mouse splenocyte.
Clone DCS-83
Isotype IgG1
Specificity This antibody reacts with Cdk6.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse and Rat.
Purification Protein-A Sepharose Chromatography.
Alternative Name CDK6 (CDK6 Antibody Abstract)
Background Cdk6 (Cyclin-dependent kinase-6) is a 38-40 kDa member of the Cdk family of mitotic kinases involved in cell cycle progression. The Cdk6 phosphoprotein, like Cdk4, associates with D-cyclins to regulate cell proliferation. Following translocation to the nucleus, the Cdk6 is phosphorylated by CAK, and the Cdk6 complex, in association with PCNA, phosphorylates the retinoblastoma (Rb) protein. Overexpression of Cdk6 has been associated with several different types of cancer.Synonyms: Cell division protein kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE
Gene ID 1021
NCBI Accession NP_001250
UniProt Q00534
Research Area Cell Cycle
Pathways Cell Division Cycle, Mitotic G1-G1/S Phases
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50 % Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
Background publications Tsubari, Taipale, Tiihonen, Keski-Oja, Laiho: "Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity." in: Molecular and cellular biology, Vol. 19, Issue 5, pp. 3654-63, 1999 (PubMed).

Lukas, Jensen, Bartkova, Lukas, Bartek: "Immunohistochemical analysis of the D-type cyclin-dependent kinases Cdk4 and Cdk6, using a series of monoclonal antibodies." in: Hybridoma, Vol. 18, Issue 3, pp. 225-34, 1999 (PubMed).