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78 kDa glucose-regulated protein antibody
| Antigen | 78 kDa glucose-regulated protein |
| Clonality | Monoclonal (4G1-B3-C4) |
| Host |
Mouse |
| Reactivity |
Human |
| Application |
ELISA, Western Blotting (WB)
|
| Catalog no. | ABIN488215 |
| Quantity | 100µg (1. 000mg/ml) |
| Price | 497.14 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Gene ID | HSPA5 |
| Swiss-Prot | P11021 |
| Immunogen | Recombinant fragment, corresponding to amino acids 487aa-638aa of human HSPA5(C-terminus) |
| Format | Purified |
| Isotype | IgG1 (Matching secondary antibodies) |
| Clone | 4G1-B3-C4 |
| Description | The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. Caution hazardous ingredient: Sodium azide, avoid exposure to skin and eyes, ingestion, and contact with heat, acids, and metals or metal ions. Wash exposed skin with soap and water. Flush eyes with water. Do not discard into plumbing. |
| Specificity | Mouse monoclonal to HSPA5 |
Application Details
| Application Notes | ELISA: 1/5000 – 1/20000. WB: 1/100-1/2000 |
| Concentration | 1. 000mg/ml |
| Purity | > 90% |
| Purification | Protein G-Sepharose affinity purified |
| Buffer | Preservative: 0. 02% Sodium Azide and 50% glycerol, 1% BSA, PBS, PH7. 4. |
| Storage | Store at -20°C. Avoid repeated freeze / thaw cycles. Ship at 4°-10° |
| Research Area | Cell/Tissue Markers, Organelles |
| Restrictions | For Research Use only |
