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Mothers Against Decapentaplegic Homolog 1 (SMAD1) antibody
| Antigen | Mothers Against Decapentaplegic Homolog 1 (SMAD1) |
| Clonality | Monoclonal (2G9-G9-C12) |
| Host |
Mouse |
| Reactivity |
Human |
| Application |
ELISA, Western Blotting (WB)
|
| Catalog no. | ABIN488228 |
| Quantity | 100µg (1. 000mg/ml) |
| Price | 497.14 $ Plus shipping costs $35.00 |
| Shipping to |
|
| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Alternative name | Mothers against decapentaplegic homolog 1 |
| Gene ID | SMAD1 |
| Swiss-Prot | Q15797 |
| Immunogen | Recombinant fragment, corresponding to amino acids 325aa-455aa of human SMAD1 (C-terminus). |
| Format | Purified |
| Isotype | IgG1 (Matching secondary antibodies) |
| Clone | 2G9-G9-C12 |
| Description | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. Caution hazardous ingredient: Sodium azide, avoid exposure to skin and eyes, ingestion, and contact with heat, acids, and metals or metal ions. Wash exposed skin with soap and water. Flush eyes with water. Do not discard into plumbing. |
| Specificity | Mouse monoclonal to SMAD1 |
Application Details
| Application Notes | ELISA: 1/5000 – 1/20000. WB: 1/100-1/2000 |
| Concentration | 1. 000mg/ml |
| Purity | > 90% |
| Purification | Protein G-Sepharose affinity purified |
| Buffer | Preservative: 0. 02% Sodium Azide and 50% glycerol, 1% BSA, PBS, PH7. 4. |
| Storage | Store at -20°C. Avoid repeated freeze / thaw cycles. Ship at 4°-10° |
| Research Area | Cancer, Growth Factors, Stem Cells, Signaling, Cytoplasmatic Domain, Chromatin and Nuclear Signaling |
| Restrictions | For Research Use only |
