ACVR2A antibody (AA 421-513)

Catalog No. ABIN4886422

Product Details anti-ACVR2A Antibody

Target: ACVR2A (Activin A Receptor, Type IIA (ACVR2A))

Binding Specificity: AA 421-513

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Activin receptor type-2A(ACVR2A) detection. Tested with WB, IHC-P in Human,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Activin receptor type-2A(ACVR2A) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: activin A receptor type 2A
Protein Name: Activin receptor type-2A

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human ACVR2A recombinant protein (Position: Q421-L513). Human ACVR2A shares 100% and 98.9% amino acid (aa) sequence identity with mouse and rat ACVR2A, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for ACVR2A

Target: ACVR2A (Activin A Receptor, Type IIA (ACVR2A))

Alternative Name: ACVR2A (ACVR2A Products)

Synonyms: ACVR2 antibody, ACVR2A antibody, XSTK9 antibody, actrii antibody, acvr2 antibody, ACTRII antibody, Acvr2 antibody, rActR-II antibody, actr2a antibody, acvr2a antibody, wu:fa02e10 antibody, ActrIIa antibody, TactrII antibody, activin A receptor type 2A antibody, activin A receptor type 2A L homeolog antibody, activin A receptor type 2Aa antibody, activin receptor IIA antibody, ACVR2A antibody, acvr2a antibody, Acvr2a antibody, acvr2a.L antibody, acvr2aa antibody

Background: Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Synonyms: ACTR 2 | ACTR2 | ACTR IIA | ACTRIIA | ACTR-IIA | ACTRII | Acvr 2 | Acvr2 | Acvr 2A | Acvr2A | P27037

Gene ID: 92

UniProt: P27037