ACVR2B antibody (C-Term)
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- Target See all ACVR2B Antibodies
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
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Binding Specificity
- AA 431-466, C-Term
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ACVR2B antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purpose
- Rabbit IgG polyclonal antibody for Activin receptor type-2B(ACVR2B) detection. Tested with WB in Human,Rat.
- Sequence
- VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAE
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Activin receptor type-2B(ACVR2B) detection. Tested with WB in Human,Rat.
Gene Name: activin A receptor type 2B
Protein Name: Activin receptor type-2B - Purification
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence at the C-terminus of human ACVR2B (431-466aa VVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAE), identical to the related mouse and rat sequences.
- Isotype
- IgG
- Top Product
- Discover our top product ACVR2B Primary Antibody
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- Target
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Alternative Name
- ACVR2B (ACVR2B Products)
- Synonyms
- ACVR2B antibody, XAR1 antibody, actr-iib antibody, actriib antibody, ACTRIIB antibody, ActR-IIB antibody, HTX4 antibody, ActRIIB antibody, actr2b antibody, actrIIb antibody, wu:fj97d11 antibody, activin A receptor type 2B antibody, activin A receptor type 2B L homeolog antibody, activin A receptor type 2Ba antibody, activin receptor IIB antibody, ACVR2B antibody, acvr2b antibody, acvr2b.L antibody, Acvr2b antibody, acvr2ba antibody
- Background
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Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This ACVR2B gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Synonyms: ActRIIB | ActR-IIB | ActR IIB | ACVR2B | ACVR-2B | ACVR 2B | HTX4 | MGC116908 | Q13705 - Gene ID
- 93
- UniProt
- Q13705
- Pathways
- Hormone Transport, Cancer Immune Checkpoints
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