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CDCP1 antibody (AA 582-667)

CDCP1 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN4886532
  • Target See all CDCP1 Antibodies
    CDCP1 (CUB Domain Containing Protein 1 (CDCP1))
    Binding Specificity
    • 11
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 582-667
    Reactivity
    • 64
    • 21
    • 11
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 39
    • 24
    • 2
    • 2
    • 1
    Rabbit
    Clonality
    • 43
    • 24
    Polyclonal
    Conjugate
    • 34
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    This CDCP1 antibody is un-conjugated
    Application
    • 39
    • 30
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for CUB domain-containing protein 1(CDCP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for CUB domain-containing protein 1(CDCP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: CUB domain containing protein 1
    Protein Name: CUB domain-containing protein 1
    Purification
    Immunogen affinity purified.
    Immunogen
    E. coli-derived human CDCP1 recombinant protein (Position: R582-T667). Human CDCP1 shares 84.5% amino acid (aa) sequence identity with mouse CDCP1.
    Isotype
    IgG
    Top Product
    Discover our top product CDCP1 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    CDCP1 (CUB Domain Containing Protein 1 (CDCP1))
    Alternative Name
    CDCP1 (CDCP1 Products)
    Synonyms
    CD318 antibody, SIMA135 antibody, TRASK antibody, 9030022E12Rik antibody, AA409659 antibody, E030027H19Rik antibody, RGD1305578 antibody, zgc:113071 antibody, CUB domain containing protein 1 antibody, CUB domain containing protein 1a antibody, CDCP1 antibody, Cdcp1 antibody, cdcp1a antibody
    Background
    CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.

    Synonyms: CD 318 | CD318 | CD318 antigen | CDCP 1 | CDCP1 | SIMA 135 | SIMA135 | TRASK | Q9H5V8
    Gene ID
    64866
    UniProt
    Q9H5V8
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