IL-1 R1 antibody
| Antigen |
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| Clonality |
Monoclonal (JAMA-147) |
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Host
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Reactivity
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Application
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Flow Cytometry (FACS), Immunoprecipitation (IP)
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| Catalog no. |
ABIN488769 |
| Quantity |
50 µg (0.1 mg/ml) |
| Price |
70.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 3 to 10 Business Days |
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Isotype
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IgG (Matching secondary antibodies)
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Clone
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JAMA-147
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Description
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IL-1 was one of the first cytokines to be described. The IL-1 family consists of three members including IL-1a, IL-1 and IL-1 receptor antagonist (IL-1Ra). IL-1a and IL-1 produce similar or identical biological responses and IL-1Ra is an endogenous inhibitor that blocks and buffers IL-1a and IL-1 actions. Each family member is expressed by a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. IL-1a is retained inside of the cell or is expressed on the cell surface and acts as an autocrine messenger, while IL-1 is secreted. IL-1a and IL-1 elicit a broad range of actions including induction of fever, hypotension, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Binding of IL-1a by ALF-161 neutralizes the biological effects of IL-1a.
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Specificity
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Armenian Hamster Anti-Mouse IL-1 R1 (Clone JAMA-147) recognizes Mouse IL-1 R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
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Application Notes
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FC, IP. Each Investigator should determine their own optimal working dilution for specific applications.
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Concentration
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0.1 mg/ml
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Purification
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Purified
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Buffer
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This purified antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Storage and Stability This antibody is stable when stored at 2-8C. Do not freeze. Reported Applications FC
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Storage
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This antibody is stable when stored at 2-8°C. Do not freeze.
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Restrictions
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For Research Use only
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Alternatives for antigen "IL-1 R1", type "Antibodies"
Alternatives 
