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Antibodies
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anti-Interleukin 1, beta (IL1B) antibody
Interleukin 1, beta (IL1B) antibody
| Antigen |
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| Synonyms |
IL-1, IL1F2, IL1-BETA, IL1B, IL-1BETA, MGC111873, zgc:111873, IL-1B |
| Clonality |
Monoclonal (B122) |
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Host
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Reactivity
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Application
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 Alternatives Immunohistochemistry (IHC), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
Western Blotting (WB) (66), Enzyme Immunoassay (EIA) (43), ELISA (34), Functional Studies (Func) (13), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), Immunohistochemistry (IHC) (11), Immunoprecipitation (IP) (8), ELISA (Detection) (6), Flow Cytometry (FACS) (5), Neutralization (Neut) (5), ELISA (Capture) (4), Immunofluorescence (IF) (4), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Dot Blot (Dot) (2), Radioimmunoassay (RIA) (2), Blocking Antibody (Inhibition) (1), Immunocytochemistry (ICC) (1), Intracellular Staining (IS) (1)
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| Catalog no. |
ABIN488773 |
| Quantity |
50 µg (0.1 mg/ml) |
| Price |
80.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 3 to 10 Business Days |
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Alternative name
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IL-1beta
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Isotype
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IgG (Matching secondary antibodies)
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Clone
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B122
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Description
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Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes.1,2 IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease.3
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Specificity
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Anti-Mouse IL-1 (Clone B122) recognizes Mouse IL-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
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Application Notes
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IHC (NBF/Par.), IP, WB. Each Investigator should determine their own optimal working dilution for specific applications.
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Concentration
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0.1 mg/ml
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Purification
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Purified
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Buffer
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This purified antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Storage and Stability This antibody is stable for at least one week when stored at 2-8C. For long term sto
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Storage
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This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "Interleukin 1, beta (IL1B)", type "Antibodies"
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Hosts
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Mouse (54), Rabbit (50), Goat (2), Rat (2), Sheep (2)
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Reactivities
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Human (68), Mouse (Murine) (15), Rat (Rattus) (12), Cow (Bovine) (5), Sheep (Ovine) (4), Monkey (2), Chicken (1), Goat (1), Pig (Porcine) (1), Rabbit (1)
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Applications
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Western Blotting (WB) (66), Enzyme Immunoassay (EIA) (43), ELISA (34), Functional Studies (Func) (13), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), Immunohistochemistry (IHC) (11), Immunoprecipitation (IP) (8), ELISA (Detection) (6), Flow Cytometry (FACS) (5), Neutralization (Neut) (5), ELISA (Capture) (4), Immunofluorescence (IF) (4), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Dot Blot (Dot) (2), Radioimmunoassay (RIA) (2), Blocking Antibody (Inhibition) (1), Immunocytochemistry (ICC) (1), Intracellular Staining (IS) (1)
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Conjugates
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Biotin (12), FITC (5), HRP (1)
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Epitopes
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Cleaved-Asp210 (2)
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