Tumor Necrosis Factor (TNF) antibody

Details for Product No. ABIN488806
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Antigen
Synonyms TNF, tnf, dif, tnfa, xtnf, TNF-a, tnfsf2, tnf-alpha, TNF-alpha, DIF, TNFA, TNFSF2, TNFalpha, Tnfa, Tnfsf1a, RATTNF, TNFa, cTNF, TNF-ALPHA, Cachectin, Tnf-alpha, tnfa-like
Reactivity
Mouse (Murine)
(468), (201), (98), (35), (35), (32), (22), (19), (10), (8), (8), (5), (5), (4), (4), (4), (2), (2), (1), (1)
Host
Armenian Hamster
(335), (273), (86), (23), (17), (12), (8), (4), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(80), (50), (32), (10), (8), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Western Blotting (WB)
(394), (380), (196), (118), (91), (83), (67), (64), (61), (57), (55), (32), (29), (21), (20), (19), (18), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

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Catalog No. ABIN488806
143.00 $
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Clone TN3-19-12
Isotype IgG
Specificity Armenian Hamster Anti-Mouse TNFa (Clone TN3-19.12) recognizes Mouse TNFa.
Purification This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Alternative Name TNFa
Background The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity.1 It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites.2 TNF-α is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-α secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-α has been detected in synovial fluid of patients with rheumatoid arthritis.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1 % BSA and 0.09 % sodium azide as a preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid Repeated Freeze Thaw Cycles.
Storage 4 °C
Storage Comment This antibody is stable for at least one week when stored at 2-8 °C. For long term storage, aliquot in working volumes without diluting and store at - 20 °C in a manual defrost freezer.
Product cited in: Taylor, Wilkison, Voyich et al.: "Prevention of bone marrow cell apoptosis and regulation of hematopoiesis by type I IFNs during systemic responses to pneumocystis lung infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 10, pp. 5956-67, 2011 (PubMed). Further details: Anti

Ermann, Garrett, Kuchroo et al.: "Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 17, pp. 7137-41, 2011 (PubMed).

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