IL-6 Receptor antibody (Interleukin-6 Receptor) (AA 20-339)

Details for Product anti-IL6R Antibody No. ABIN4899502, Supplier: Log in to see
Antigen
  • IL6R
  • il-6ra
  • CD126
  • IL-6R-1
  • IL-6RA
  • IL6Q
  • IL6RA
  • IL6RQ
  • gp80
  • IL6R1
  • Il6ra
  • IL-6Ralpha
  • IL-6R
  • Il6r
  • interleukin 6 receptor
  • interleukin 6 receptor-like
  • interleukin 6 receptor, alpha
  • IL6R
  • il6r
  • Il6r
  • LOC100347752
  • Il6ra
Alternatives
anti-Human IL-6 Receptor antibody for Flow Cytometry
Epitope
AA 20-339
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Reactivity
Human
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97
46
1
Host
Mouse
130
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52
23
2
Clonality (Clone)
Monoclonal ()
Conjugate
This IL-6 Receptor antibody is un-conjugated
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Application
Cytometry by Time of Flight (CyTOF), ELISA (Capture), Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-6 R, Leu20-Asp339, Accession # P08887
Clone 17506
Isotype IgG1
Specificity Detects human IL-6 R in ELISAs and Western blots. In ELISAs, no cross-reactivity or interference was observed with recombinant human (rh) IL-1 alpha , recombinant mouse (rm) IL-1 alpha , rhIL-1 beta , rmIL-1 beta , rhIL-1ra, rhIL-2, rhIL-3, rmIL-3, rhIL-4, rmIL-4, rhIL-5, rmIL-5, rhIL-6, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL-10, or rhIL-11.
Purification Protein A or G purified from hybridoma culture supernatant
Sterility 0.2 μm filtered
Endotoxin Level <0.10 EU per 1 μg of the antibody by the LAL method.
Alternative Name IL-6 R alpha (IL6R Antibody Abstract)
Gene ID 3570
UniProt P08887
Research Area Stem Cells, Hematopoietic Progenitors, Immunology, Cytokines, Innate Immunity
Pathways JAK-STAT Signaling, Autophagy, Growth Factor Binding
Application Notes Western Blot 1 μg/mL
Flow Cytometry 0.25 μg/10^6 cells
Neutralization 0.04-0.2 μg/mL
CyTOF-ready
ELISA Capture (Matched Antibody Pair) 2-8 μg/mL
Restrictions For Research Use only
Reconstitution Reconstitute at 0.5 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months
Supplier Images
Neutralization (Neut) image for anti-Interleukin-6 Receptor (IL6R) (AA 20-339) antibody (ABIN4899502) IL-6 R alpha Enhancement of IL-6-dependent Inhibition of Cell Proliferation and Neutr...
Flow Cytometry (FACS) image for anti-Interleukin-6 Receptor (IL6R) (AA 20-339) antibody (ABIN4899502) Detection of IL-6 R alpha in U937 Human Cell Line by Flow Cytometry. U937 human histi...
Flow Cytometry (FACS) image for anti-Interleukin-6 Receptor (IL6R) (AA 20-339) antibody (ABIN4899502) Detection of IL-6 R alpha in U937 Human Cell Line by Flow Cytometry. U937 human histi...
Western Blotting (WB) image for anti-Interleukin-6 Receptor (IL6R) (AA 20-339) antibody (ABIN4899502) Detection of Recombinant Human IL-6 R alpha by Western Blot. Western blot shows 25 ng...
Neutralization (Neut) image for anti-Interleukin-6 Receptor (IL6R) (AA 20-339) antibody (ABIN4899502) IL-6 R alpha Enhancement of IL-6-dependent Inhibition of Cell Proliferation and Neutr...
Product cited in: Uchibori, Matsuda, Shimodaira, Sugano, Uehara, Honda: "IL-6 trans-signaling is another pathway to upregulate Osteopontin." in: Cytokine, Vol. 90, pp. 88-95, 2016 (PubMed). Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Munir, Luu, Clarke, Nash, McGettrick: "Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155161, 2016 (PubMed). Method employed by authors: Neutralization (Neut) (Sample species: Human).

Sommer, Fabri: "Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells." in: PLoS ONE, Vol. 10, Issue 6, pp. e0130395, 2015 (PubMed). Method employed by authors: Neutralization (Neut) (Sample species: Human).

Zielinski, Mele, Aschenbrenner, Jarrossay, Ronchi, Gattorno, Monticelli, Lanzavecchia, Sallusto: "Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β." in: Nature, Vol. 484, Issue 7395, pp. 514-8, 2012 (PubMed). Method employed by authors: Neutralization (Neut) (Sample species: Human).

Nieman, Kenny, Penicka, Ladanyi, Buell-Gutbrod, Zillhardt, Romero, Carey, Mills, Hotamisligil, Yamada, Peter, Gwin, Lengyel: "Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth." in: Nature medicine, Vol. 17, Issue 11, pp. 1498-503, 2011 (PubMed). Method employed by authors: In vivo Studies (in vivo) (Sample species: Human).

Ara, Song, Shimada, Keshelava, Russell, Metelitsa, Groshen, Seeger, DeClerck: "Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells." in: Cancer research, Vol. 69, Issue 1, pp. 329-37, 2009 (PubMed). Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Duhen, Geiger, Jarrossay, Lanzavecchia, Sallusto: "Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells." in: Nature immunology, Vol. 10, Issue 8, pp. 857-63, 2009 (PubMed). Method employed by authors: Neutralization (Neut) (Sample species: Human).

Kolliputi, Waxman: "IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation." in: American journal of respiratory cell and molecular biology, Vol. 40, Issue 3, pp. 314-24, 2009 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

Acosta-Rodriguez, Napolitani, Lanzavecchia, Sallusto: "Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells." in: Nature immunology, Vol. 8, Issue 9, pp. 942-9, 2007 (PubMed). Method employed by authors: Neutralization (Neut) (Sample species: Human).

Ammit, Moir, Oliver, Hughes, Alkhouri, Ge, Burgess, Black, Roth: "Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 1, pp. L199-206, 2007 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

Mozaffarian, Rimm, King, Lawler, McDonald, Levy: "trans fatty acids and systemic inflammation in heart failure." in: The American journal of clinical nutrition, Vol. 80, Issue 6, pp. 1521-5, 2004 (PubMed). Method employed by authors: ELISA (ELISA) (Sample species: Human).

Hurst, McLoughlin, Monslow, Owens, Morgan, Fuller, Topley, Jones: "Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 9, pp. 5244-51, 2002 (PubMed). Method employed by authors: ELISA (ELISA) (Sample species: Human).

Erices, Conget, Rojas, Minguell: "Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells." in: Experimental cell research, Vol. 280, Issue 1, pp. 24-32, 2002 (PubMed). Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Hurst, Wilkinson, McLoughlin, Jones, Horiuchi, Yamamoto, Rose-John, Fuller, Topley, Jones: "Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation." in: Immunity, Vol. 14, Issue 6, pp. 705-14, 2001 (PubMed). Method employed by authors: ELISA (ELISA) (Sample species: Human).

Asou, Said, Yang, Munker, Park, Kamada, Koeffler: "Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells." in: Blood, Vol. 91, Issue 7, pp. 2475-81, 1998 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

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