CDH10 antibody

Catalog No. ABIN4903221

Product Details anti-CDH10 Antibody

Target: CDH10 (Cadherin 10, Type 2 (T2-Cadherin) (CDH10))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDH10 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients.

Purification: Affinity purification

Immunogen: Recombinant protein of human CDH10.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for CDH10

Target: CDH10 (Cadherin 10, Type 2 (T2-Cadherin) (CDH10))

Alternative Name: CDH10 (CDH10 Products)

Synonyms: A830016G23Rik antibody, C030003B10Rik antibody, C030011H18Rik antibody, cadherin 10 antibody, Cdh10 antibody, CDH10 antibody

Gene ID: 1008

UniProt: Q9Y6N8

Pathways: Cell-Cell Junction Organization