LAMB2 antibody

Catalog No. ABIN4904193

Product Details anti-LAMB2 Antibody

Target: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMB2 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known.

Purification: Affinity purification

Immunogen: Recombinant protein of human LAMB2.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for LAMB2

Target: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Alternative Name: LAMB2 (LAMB2 Products)

Synonyms: LAMS antibody, NPHS5 antibody, AW211941 antibody, Lamb-2 antibody, Lams antibody, SLAM antibody, lamb1 antibody, lams antibody, LAMC1 antibody, laminin antibody, laminin subunit beta 2 antibody, laminin, beta 2 antibody, laminin subunit beta 2 L homeolog antibody, laminin, beta 2 (laminin S) antibody, LAMB2 antibody, Lamb2 antibody, lamb2.L antibody

Gene ID: 3913

UniProt: P55268

Pathways: Skeletal Muscle Fiber Development