TGFBR3 antibody

Catalog No. ABIN4905408

Product Details anti-TGFBR3 Antibody

Target: TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR3 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (1-4). TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases (5). The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain (6,7). Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription (8,9).

Purification: Affinity purification

Immunogen: Recombinant protein of human TGFBR3.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for TGFBR3

Target: TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))

Alternative Name: TGFBR3 (TGFBR3 Products)

Synonyms: TGFBR3 antibody, DKFZp469I0915 antibody, BGCAN antibody, betaglycan antibody, 1110036H20Rik antibody, AU015626 antibody, AW215636 antibody, TBRIII antibody, transforming growth factor beta receptor 3 antibody, transforming growth factor, beta receptor III antibody, TGFBR3 antibody, tgfbr3 antibody, Tgfbr3 antibody

Gene ID: 7049

UniProt: Q03167