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Lactate Dehydrogenase A antibody (N-Term)

LDHA Reactivity: Human WB, IF, EIA Host: Mouse Monoclonal AT1A4 unconjugated
Catalog No. ABIN492378
  • Target See all Lactate Dehydrogenase A (LDHA) Antibodies
    Lactate Dehydrogenase A (LDHA)
    Binding Specificity
    • 13
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-332, N-Term
    Reactivity
    • 84
    • 43
    • 33
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 95
    • 18
    • 5
    • 2
    Mouse
    Clonality
    • 101
    • 17
    Monoclonal
    Conjugate
    • 52
    • 20
    • 14
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This Lactate Dehydrogenase A antibody is un-conjugated
    Application
    • 82
    • 48
    • 43
    • 27
    • 14
    • 14
    • 11
    • 9
    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    The antibody recognizes Human LDHA. Other species not tested.
    Characteristics
    Synonyms: LDH-A, L-lactate dehydrogenase A chain, LDH-M, PIG19, NY-REN-59, LDH muscle subunit,Cell proliferation-inducing gene 19 protein, Renal carcinoma antigen NY-REN-59
    Purification
    Affinity chromatography on Protein G
    Immunogen
    Recombinant human LDHA (1-332aa) purified from E. coli
    Clone
    AT1A4
    Isotype
    IgG2b
    Top Product
    Discover our top product LDHA Primary Antibody
  • Application Notes
    ELISA. Western blot (1: 500 - 1: 8000). Immunofluorescence (1: 500 - 1: 8000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4, 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    Lactate Dehydrogenase A (LDHA)
    Alternative Name
    LDHA (LDHA Products)
    Synonyms
    GSD11 antibody, LDH1 antibody, LDHM antibody, LDH-M antibody, ldh-h antibody, ldha antibody, ldha-B antibody, ldhbb antibody, trg-5 antibody, Ldh1 antibody, Ldhm antibody, l7R2 antibody, gsd11 antibody, ldh-m antibody, ldh1 antibody, ldhm antibody, pig19 antibody, ldha1 antibody, ldhab antibody, LDH-A antibody, LDHC antibody, lactate dehydrogenase A antibody, lactate dehydrogenase B L homeolog antibody, lactate dehydrogenase A4 antibody, lactate dehydrogenase A L homeolog antibody, L-lactate dehydrogenase A chain antibody, LDHA antibody, ldhb.L antibody, Ldha antibody, ldha antibody, ldha.L antibody, LOC100713875 antibody
    Background
    Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.Synonyms: Cell proliferation-inducing gene 19 protein, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, NY-REN-59, PIG19, Renal carcinoma antigen NY-REN-59
    Gene ID
    3939
    UniProt
    P00338
    Pathways
    Warburg Effect
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