CXCR7 antibody (Chemokine (C-X-C Motif) Receptor 7) (N-Term)

Details for Product anti-CXCR7 Antibody No. ABIN492896, Supplier: Log in to see
Antigen
  • BEST:LD12308
  • CG3171
  • Dmel\\CG3171
  • LD12308
  • Tre-1
  • anon-WO0170980.16
  • anon-WO0170980.17
  • anon-WO0170981.1
  • sctt
  • tre-1
  • tre1
  • CMKOR1
  • CXC-R7
  • CXCR-7
  • CXCR7
  • GPR159
  • RDC-1
  • RDC1
  • AW541270
  • Cmkor1
  • Cxcr7
  • Rdc1
  • Trapped in endoderm 1
  • G protein coupled receptor
  • atypical chemokine receptor 3
  • chemokine (C-X-C motif) receptor 7
  • Tre1
  • MmrVgp88
  • ACKR3
  • Ackr3
  • Cxcr7
  • CXCR7
Alternatives
anti-Rat (Rattus) CXCR7 antibody for ELISA
Epitope
N-Term
46
26
26
15
13
11
11
11
9
6
5
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
202
108
79
7
7
6
6
4
4
4
4
3
1
1
1
1
1
1
1
Host
Rabbit
132
82
19
5
1
Clonality
Polyclonal
Conjugate
This CXCR7 antibody is un-conjugated
14
12
10
10
10
10
9
9
8
8
7
7
6
4
4
2
2
2
2
2
2
2
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
131
97
54
41
26
25
16
7
5
3
3
2
2
1
Options
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Immunogen Synthetic peptide (selective for CXCR7 receptor N-terminal region)
Specificity This antibody detects a single 52-53 kDa CXCR7.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography
Alternative Name CXCR7 / GPR159 (CXCR7 Antibody Abstract)
Background Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases Several subtypes of CXCR have been characterized. Activation of naive T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Chemokine receptor type 3 (CXCR3) is induced during T cell activation and CXCR3 positive cell are enriched at the inflammatory site (2). On the contrary, glucocorticoid dexamethasone has potent anti-inflammatory effects, yet it up-regulates expression of CXCR4 but not that of CXCR1 and CXCR3 (4). The chemokine receptor 7 protein is approximately 43-44 kDa (378 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The all CXCR sequence analyses suggest the presence of 7 transmembrane domains, a characteristic feature of GPCR. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites. The Anti-CXCR-selective antibodies were generated against conserved but unique sequences on various CXCR receptors that are expressed only in a particular CXCR receptor subtype.Synonyms: C-X-C chemokine receptor type 7, CMKOR1, CXC-R7, CXCR-7, Chemokine orphan receptor 1, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, GPR-159, RDC1
Gene ID 57007
NCBI Accession NP_064707
UniProt P25106
Pathways Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling
Application Notes Immunohistochemistry on frozen sections. Western blot: 1: 500. ELISA. IMM and i. p pull-down assays: > 1: 250.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.685 - 1.25 mg/mL
Buffer Stabilization buffer with preservative
Preservative Other preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Background publications Tran, Miller: "Chemokine receptors: signposts to brain development and disease." in: Nature reviews. Neuroscience, Vol. 4, Issue 6, pp. 444-55, 2003 (PubMed).

Xie, Nomura, Lu, Chen, Koch, Weng, Rosa, Di Salvo, Mudgett, Peterson, Wicker, DeMartino: "Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation." in: Journal of leukocyte biology, Vol. 73, Issue 6, pp. 771-80, 2003 (PubMed).

Segerer: "The role of chemokines and chemokine receptors in progressive renal diseases." in: American journal of kidney diseases : the official journal of the National Kidney Foundation, Vol. 41, Issue 3 Suppl 1, pp. S15-8, 2003 (PubMed).

Ramjeesingh, Leung, Siu: "Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 17, Issue 10, pp. 1292-4, 2003 (PubMed).