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NGFR antibody (Nerve Growth Factor Receptor) (N-Term)

Details for Product anti-NGFR Antibody No. ABIN493187, Supplier: Log in to see
Antigen
  • ngfr
  • wu:fb38c02
  • wu:fc10h01
  • CD271
  • Gp80-LNGFR
  • TNFRSF16
  • p75(NTR)
  • p75NTR
  • LNGFR
  • RNNGFRR
  • Tnfrsf16
  • p75
  • NRH1b
  • fullback
  • nrh1
  • p75ntr
  • tnfrsf16
  • p75NGFR
Alternatives
anti-Human NGFR antibody for Flow Cytometry
Epitope
N-Term
23
20
15
13
9
7
7
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
244
92
81
19
17
15
14
12
9
8
6
5
2
1
1
1
1
1
Host
Rabbit
129
109
32
4
1
Clonality
Polyclonal
Conjugate
This NGFR antibody is un-conjugated
15
15
13
12
5
4
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
186
106
79
78
62
41
33
30
13
13
11
7
6
4
4
2
1
1
Supplier
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Immunogen Synthetic peptide selected from the N-term of the protein unique to P-75NTR
Specificity This antibody detects CD271 / NGFR at N-term (76 kDa).
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography
Alternative Name CD271 / NGFR (NGFR Antibody Abstract)
Background The pan-neurotrophin receptor p75NTR belongs to a large family of receptors, which includes tumor necrosis factor receptors (TNF), Fas and approximately 25 other members. The p75NTR is the first receptor to be cloned and have shown significant advancement in its understanding of signaling pathways. In the last several years considerable advancement have been made regarding the signaling pathways activated by p75NTR and its potential biological functions. It is now known that P75NTR has surprisingly diverse effects, ranging from cell death to regulation of axon elongation. This diversity in its physiological effects can be explained by the complex formation of p75NTR with other receptors and multiple signaling molecules that interact with the intracellular domain of p75NTR (1). Neuronal survival, differentiation and mylination also involves p75NTR signaling via Trk receptor kinases. Identification of new ligands, cytosolic interacting partners, receptor cleavage products and coreceptors for the p75NTR led to greater understanding of p75NTR signaling (2). Nerve growth factor (NGF) is synthesized by various structural and inflammatory cells and activates Tropomyosin-receptor kinase A (TrkA) and the p75NTR receptor, both belong to the Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
Gene ID 4804
NCBI Accession NP_002498
UniProt P08138
Research Area Growth Factors, Receptors
Pathways NF-kappaB Signaling, Neurotrophin Signaling Pathway
Application Notes Immunohistochemistry on frozen sections. ELISA. Western blot: > 1: 500. Immunoprecipitation and i. p pull-down assays: > 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.50 - 0.95 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
 image for anti-NGFR antibody (Nerve Growth Factor Receptor) (N-Term) (ABIN493187) anti-Nerve Growth Factor Receptor (NGFR) (N-Term) antibody
Background publications Yamashita, Fujitani, Hata et al.: "Diverse functions of the p75 neurotrophin receptor." in: Anatomical science international, Vol. 80, Issue 1, pp. 37-41, 2005 (PubMed).

Nykjaer, Willnow, Petersen: "p75NTR--live or let die." in: Current opinion in neurobiology, Vol. 15, Issue 1, pp. 49-57, 2005 (PubMed).

Linggi, Burke, Williams et al.: "Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13801-8, 2005 (PubMed).

Allen, Khwaja, Djakiew: "Gene therapy of prostate xenograft tumors with a p75NTR lipoplex." in: Anticancer research, Vol. 24, Issue 5A, pp. 2997-3003, 2004 (PubMed).