Nerve Growth Factor Receptor (NGFR) (N-Term) antibody

Details for Product No. ABIN493187
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Antigen
Synonyms ngfr, wu:fb38c02, wu:fc10h01, CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, LNGFR, RNNGFRR, Tnfrsf16, p75, NRH1b, fullback, nrh1, p75ntr, tnfrsf16, p75NGFR
Epitope
N-Term
(11), (10), (7), (7), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(150), (80), (77), (35), (14), (13), (13), (8), (7), (5), (3), (3), (1), (1), (1), (1)
Host
Rabbit
(109), (51), (11), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunoprecipitation (IP), Western Blotting (WB)
(121), (58), (43), (40), (34), (34), (30), (24), (18), (18), (10), (4), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN493187
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Immunogen Synthetic peptide selected from the N-term of the protein unique to P-75NTR
Specificity This antibody detects CD271 / NGFR at N-term (76 kDa).
Purification Affinity chromatography
Alternative Name CD271 / NGFR
Background The pan-neurotrophin receptor p75NTR belongs to a large family of receptors, which includes tumor necrosis factor receptors (TNF), Fas and approximately 25 other members. The p75NTR is the first receptor to be cloned and have shown significant advancement in its understanding of signaling pathways. In the last several years considerable advancement have been made regarding the signaling pathways activated by p75NTR and its potential biological functions. It is now known that P75NTR has surprisingly diverse effects, ranging from cell death to regulation of axon elongation. This diversity in its physiological effects can be explained by the complex formation of p75NTR with other receptors and multiple signaling molecules that interact with the intracellular domain of p75NTR (1). Neuronal survival, differentiation and mylination also involves p75NTR signaling via Trk receptor kinases. Identification of new ligands, cytosolic interacting partners, receptor cleavage products and coreceptors for the p75NTR led to greater understanding of p75NTR signaling (2). Nerve growth factor (NGF) is synthesized by various structural and inflammatory cells and activates Tropomyosin-receptor kinase A (TrkA) and the p75NTR receptor, both belong to the “death receptor” family. One of the several diverse effects of p75NTR signaling is neuronal apoptosis that requires interaction of neurotrophin receptor interacting factor (NRIF) with c-Jun-N-terminal kinase (JNK) and p53 activation (3). The p75NTR has been characterized as a tumor suppressor in human prostate cancer. Administration of the p75NTR gene into subcutaneous PC-3 xenografts suppressed in a dose-dependent manner the growth of tumors (4). P75NTR has multiple functional domains including a NTRF and a C- terminal Death domain.
Alternate names: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
Gene ID 4804
NCBI Accession NP_002498
UniProt P08138
Research Area Growth Factors, Receptors
Application Notes Immunohistochemistry on frozen sections. ELISA. Western blot: > 1: 500. Immunoprecipitation and i. p pull-down assays: > 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.50 - 0.95 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Supplier Images
anti-Nerve Growth Factor Receptor (NGFR) (N-Term) antibody anti-Nerve Growth Factor Receptor (NGFR) (N-Term) antibody
Background publications Allen, Khwaja, Djakiew: "Gene therapy of prostate xenograft tumors with a p75NTR lipoplex." in: Anticancer research, Vol. 24, Issue 5A, pp. 2997-3003, 2004 (PubMed).

Linggi, Burke, Williams et al.: "Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13801-8, 2005 (PubMed).

Nykjaer, Willnow, Petersen: "p75NTR--live or let die." in: Current opinion in neurobiology, Vol. 15, Issue 1, pp. 49-57, 2005 (PubMed).

Yamashita, Fujitani, Hata et al.: "Diverse functions of the p75 neurotrophin receptor." in: Anatomical science international, Vol. 80, Issue 1, pp. 37-41, 2005 (PubMed).

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