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ADCY2 antibody (Adenylate Cyclase 2 (Brain))

Details for Product anti-ADCY2 Antibody No. ABIN493191, Supplier: Log in to see
  • AC2
  • ADCY2
  • HBAC2
  • mKIAA1060
anti-Human ADCY2 antibody for Enzyme Immunoassay
Human, Mouse (Murine), Rat (Rattus)
This ADCY2 antibody is un-conjugated
Western Blotting (WB)
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Immunogen Synthetic peptide unique to PAC-2 protein
Specificity This antibody detects Adenylate cyclase type 2. Labels a 110-112 kDa protein in Western blot.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography
Alternative Name Adenylate Cyclase Type 2 (ADCY2 Antibody Abstract)
Background The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier (1). The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc., (3, 4). The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of Gsa to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase (5). In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes.Synonyms: ADCY2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, KIAA1060
Gene ID 108
NCBI Accession NP_065433
UniProt Q08462
Pathways EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Western blot: 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.75 - 1.2 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
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 image for anti-ADCY2 antibody (Adenylate Cyclase 2 (Brain)) (ABIN493191) anti-Adenylate Cyclase 2 (Brain) (ADCY2) antibody
Background publications Taussig, Tang, Hepler, Gilman: "Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases." in: The Journal of biological chemistry, Vol. 269, Issue 8, pp. 6093-100, 1994 (PubMed).

Bourne, Sanders, McCormick: "The GTPase superfamily: a conserved switch for diverse cell functions." in: Nature, Vol. 348, Issue 6297, pp. 125-32, 1990 (PubMed).

Gilman: "G proteins: transducers of receptor-generated signals." in: Annual review of biochemistry, Vol. 56, pp. 615-49, 1987 (PubMed).