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SOCS1 antibody (Suppressor of Cytokine Signaling 1)

Details for Product anti-SOCS1 Antibody No. ABIN493470, Supplier: Login to see
Antigen
  • socs1
  • zgc:91868
  • jab
  • cis1
  • ssi1
  • tip3
  • cish1
  • ssi-1
  • socs-1
  • SOCS1
  • LOC100228306
  • socs1b
  • CIS1
  • CISH1
  • JAB
  • SOCS-1
  • SSI-1
  • SSI1
  • TIP3
  • Cish1
  • Cish7
  • Socs-1
Alternatives
anti-Human SOCS1 antibody for ELISA
Reactivity
Human
153
66
55
8
8
4
2
2
1
Host
Rabbit
136
19
10
Clonality
Polyclonal
Conjugate
This SOCS1 antibody is un-conjugated
7
7
6
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
142
57
35
30
11
10
9
7
4
4
2
1
Supplier
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Immunogen Synthetic peptides corresponding to unique epitope on SOCS1. The SOCS1 peptide was post-synthetically covalently modified to achieve desired antigenicity.
Isotype IgG
Specificity This antibody detects a single band of approximately 25 kDa.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on immobilized antigen
Alternative Name SOCS1 (SOCS1 Antibody Abstract)
Background Suppressor of cytokine signaling 1 (SOCS1) is a member of the SOCS family of proteins, consisting of eight members (SOCS1 to SOCS7 and CIS) all sharing a central SH2 domain and a c-terminal SOCS box (1). This family is involved in inducible feedback inhibition of janus kinases (JAKs) and signal transducers and activators of transcription (STATs) signaling pathway, which plays multiple roles in cell growth, differentiation, and apoptosis (2). SOCS1 is located on chromosome 16 (3). It plays a key role in the negative regulation of IFN-gamma signaling and in T-cell differentiation. SOCS1 inhibits macrophage differentiation of M1 cells in response to IL-6, protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates JAKs to suppress ROS-mediated apoptosis (2, 4). It translocates into the nucleus due to the presence of a functional nuclear localization signal (NLS). It also regulates IFN-gamma mediated sensory neuronal survival. SOCS1 is implicated in various cancers and diseases. Mutations of SOCS1 are found in classic Hodgkin lymphoma and primary mediastinal B-cell lymphoma (5). It is induced in response to TNF-alpha or H2O2 and by a subset of cytokines including those belonging to interferon, interleukin and colony stimulating factor colonies. It attenuates their signaling by its ability to bind and inhibit all four of the JAKs. It is found to colocalize and biochemically copurify with the microtubule organizing complex (MTOC) and its associated 20S proteasome (6). It is expressed in all tissues with high expression in spleen, small intestine and peripheral blood lymphocytes. It is approximately a 25 kDa protein (211 amino acids).Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
Molecular Weight approx. 25 kDa
Gene ID 8651
NCBI Accession NP_003736
UniProt O15524
Research Area Chromatin and Nuclear Signaling, Signaling, Cytokines
Pathways JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling
Application Notes This antibody is ideal for ELISA (< 1/10,000) and Western Blot (> 1/500).
Restrictions For Research Use only
Concentration 0.64-0.72 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20 °C.
Background publications Oh, Hur, Lee: "SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis." in: Oncogene, Vol. 28, Issue 35, pp. 3145-56, 2009 (PubMed).

Weniger, Melzner, Menz et al.: "Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation." in: Oncogene, Vol. 25, Issue 18, pp. 2679-84, 2006 (PubMed).

Vuong, Arenzana, Showalter et al.: "SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome." in: Molecular and cellular biology, Vol. 24, Issue 20, pp. 9092-101, 2004 (PubMed).

Yandava, Pillari, Drazen: "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively." in: Genomics, Vol. 61, Issue 1, pp. 108-11, 1999 (PubMed).

Starr, Willson, Viney et al.: "A family of cytokine-inducible inhibitors of signalling." in: Nature, Vol. 387, Issue 6636, pp. 917-21, 1997 (PubMed).