Suppressor of Cytokine Signaling 1 (SOCS1) antibody

Details for Product No. ABIN493470
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Antigen
Synonyms JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Cish1, Socs-1, Cish7, socs1, zgc:91868, jab, cis1, ssi1, tip3, cish1, ssi-1, socs-1, SOCS1, LOC100228306, socs1b
Reactivity
Human
(95), (53), (44), (15), (12), (4), (1)
Host
Rabbit
(98), (10), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(101), (48), (27), (13), (10), (10), (8), (7), (5), (4), (4), (3)
Pubmed 5 references available
Catalog no. ABIN493470
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptides corresponding to unique epitope on SOCS1. The SOCS1 peptide was post-synthetically covalently modified to achieve desired antigenicity.
Isotype IgG
Specificity This antibody detects a single band of approximately 25kDa.
Purification Affinity Chromatography on immobilized antigen
Alternative Name SOCS1 / JAB
Background Suppressor of cytokine signaling 1 (SOCS1) is a member of the SOCS family of proteins, consisting of eight members (SOCS1 to SOCS7 and CIS) all sharing a central SH2 domain and a c-terminal SOCS box (1). This family is involved in inducible feedback inhibition of janus kinases (JAKs) and signal transducers and activators of transcription (STATs) signaling pathway, which plays multiple roles in cell growth, differentiation, and apoptosis (2). SOCS1 is located on chromosome 16 (3). It plays a key role in the negative regulation of IFN-gamma signaling and in T-cell differentiation. SOCS1 inhibits macrophage differentiation of M1 cells in response to IL-6, protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates JAKs to suppress ROS-mediated apoptosis (2, 4). It translocates into the nucleus due to the presence of a functional nuclear localization signal (NLS). It also regulates IFN-gamma mediated sensory neuronal survival. SOCS1 is implicated in various cancers and diseases. Mutations of SOCS1 are found in classic Hodgkin lymphoma and primary mediastinal B-cell lymphoma (5). It is induced in response to TNF-alpha or H2O2 and by a subset of cytokines including those belonging to interferon, interleukin and colony stimulating factor colonies. It attenuates their signaling by its ability to bind and inhibit all four of the JAKs. It is found to colocalize and biochemically copurify with the microtubule organizing complex (MTOC) and its associated 20S proteasome (6). It is expressed in all tissues with high expression in spleen, small intestine and peripheral blood lymphocytes. It is approximately a 25kDa protein (211 amino acids).
Alternate names: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
Molecular Weight ~25 kDa
Gene ID 8651
NCBI Accession NP_003736
UniProt O15524
Application Notes This antibody is ideal for ELISA (< 1/10,000) and Western Blot (> 1/500).
Restrictions For Research Use only
Format Liquid
Concentration 0.64-0.72 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20°C.
Expiry Date 12 months
Background publications Starr, Willson, Viney et al.: "A family of cytokine-inducible inhibitors of signalling." in: Nature, Vol. 387, Issue 6636, pp. 917-21, 1997 (PubMed).

Yandava, Pillari, Drazen: "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively." in: Genomics, Vol. 61, Issue 1, pp. 108-11, 1999 (PubMed).

Vuong, Arenzana, Showalter et al.: "SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome." in: Molecular and cellular biology, Vol. 24, Issue 20, pp. 9092-101, 2004 (PubMed).

Weniger, Melzner, Menz et al.: "Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation." in: Oncogene, Vol. 25, Issue 18, pp. 2679-84, 2006 (PubMed).

Oh, Hur, Lee: "SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis." in: Oncogene, Vol. 28, Issue 35, pp. 3145-56, 2009 (PubMed).

Hosts (98), (10), (8)
Reactivities (95), (53), (44), (15), (12), (4), (1)
Applications (101), (48), (27), (13), (10), (10), (8), (7), (5), (4), (4), (3)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (31), (18), (4), (2), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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